Cited 0 times in

Duchenne 근디스트로피의 치료에 대한 고찰

Title
Duchenne 근디스트로피의 치료에 대한 고찰
Other Titles
Treatment of Duchenne Muscular Dystrophy: A Comprehensive Review
Authors
박형준;최영철
Issue Date
2012
Journal Title
대한신경과학회지
ISSN
1225-7044
Citation
대한신경과학회지, Vol.30(4) : 257~266, 2012
Abstract
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder due to the loss of dystrophin in muscle fiber. The deficiency of dystrophin produces severe progressive muscle degeneration which leads to progressive muscle weakness. Affected patients usually become unambulatory in their early teens, and suffer a respiratory failure before 20 years of age. In an attempt to improve quality of life and extend life span of DMD patients, various treatments have been challenged; corticosteroid trial, rehabilitation, cardiac and pulmonary managements, orthopedic interventions, and nutritional support. However, only corticosteroid therapy and non-invasive ventilation have shown a salutary effect on the clinical course of DMD. Recently, a better understanding of the DMD pathophysiology has provided the scientific basis for new treatment modalities including cell and molecular therapy. Although previous clinical trials have demonstrated the limitation and possibility of new therapies, antisense-mediated exon skipping technology is now emerging as a promising approach to restore dystrophin expression. This article summarizes the current challenges and recommendations of treatment approaches in DMD patients.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/92271
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurology
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T201205084.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse