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Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study.

Authors
 Byoung-Jin Park ; Yong-Jae Lee ; Jae-Yong Shim ; Hong-Bae Kim ; Ha-Young Na ; Dong-Hyuk Jung ; Hye-Ree Lee 
Citation
 가정의학회지, Vol.33(4) : 190~196, 2012 
Journal Title
 가정의학회지 
ISSN
 2005-6443 
Issue Date
2012
Abstract
BACKGROUND: This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters, inflammatory markers, and arterial stiffness in subjects with metabolic syndrome. METHODS: We performed a randomized, double-blind, placebo-controlled, single-center study in 60 subjects who were not taking drugs that could affect metabolic and vascular functions. Subjects were randomized into either a KRG (4.5 g/d) group or a placebo group for a 12-week study. We collected anthropometric measurements, blood for laboratory testing, and brachial-ankle pulse wave velocity (baPWV) at the initial (week 0) and final (week 12) visits. RESULTS: A total of 48 subjects successfully completed the study protocol. Oral administration of KRG did not significantly affect blood pressure, oxidative or inflammatory markers, or baPWV. CONCLUSION: We found no evidence that KRG had an effect on blood pressure, lipid profile, oxidized low density lipoprotein, fasting blood glucose, or arterial stiffness in subjects with metabolic syndrome. These findings warrant subsequent longer-term prospective clinical investigations with a larger population. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT00976274
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92169
DOI
10.4082/kjfm.2012.33.4.190
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Family Medicine
Yonsei Authors
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