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Serum and cerebrospinal fluid neuron-specific enolase for diagnosis of tuberculous meningitis
DC Field | Value | Language |
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dc.contributor.author | 김원주 | - |
dc.contributor.author | 송태진 | - |
dc.contributor.author | 이경열 | - |
dc.contributor.author | 최영철 | - |
dc.date.accessioned | 2014-12-19T17:50:07Z | - |
dc.date.available | 2014-12-19T17:50:07Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92147 | - |
dc.description.abstract | PURPOSE: Late diagnosis and treatment lead to high mortality and poor prognosis in tuberculous meningitis (TbM). A rapid and accurate diagnosis is necessary for a good prognosis. Neuron-specific enolase (NSE) has been investigated as a biochemical marker of nervous tissue damage. In the present study, the usefulness of NSE was evaluated, and a cut-off value for the differential diagnosis of TbM was proposed. MATERIALS AND METHODS: Patient charts were reviewed for levels of serum and cerebrospinal fluid (CSF) NSE, obtained from a diagnostic CSF study of samples in age- and gender-matched TbM (n=15), aseptic meningitis (n=28) and control (n=37) patients. RESULTS: CSF/serum NSE ratio was higher in the TbM group than those of the control and aseptic groups (p=0.001). In binary logistic regression, CSF white blood cell count and CSF/serum NSE ratio were significant factors for diagnosis of TbM. When the cut-off value of the CSF/serum NSE ratio was 1.21, the sensitivity was 86.7% and the specificity was 75.4%. CONCLUSION: The CSF/serum NSE ratio could be a useful parameter for the early diagnosis of TbM. In addition, the authors of the present study suggest a cut-off value of 1.21 for CSF/serum NSE ratio. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phosphopyruvate Hydratase/blood* | - |
dc.subject.MESH | Phosphopyruvate Hydratase/cerebrospinal fluid* | - |
dc.subject.MESH | Tuberculosis, Meningeal/blood | - |
dc.subject.MESH | Tuberculosis, Meningeal/diagnosis* | - |
dc.subject.MESH | Tuberculosis, Meningeal/metabolism | - |
dc.title | Serum and cerebrospinal fluid neuron-specific enolase for diagnosis of tuberculous meningitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Tae-Jin Song | - |
dc.contributor.googleauthor | Young-Chul Choi | - |
dc.contributor.googleauthor | Kyung-Yul Lee | - |
dc.contributor.googleauthor | Won-Joo Kim | - |
dc.identifier.doi | 23074103 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00771 | - |
dc.contributor.localId | A02073 | - |
dc.contributor.localId | A02648 | - |
dc.contributor.localId | A04116 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 23074103 | - |
dc.subject.keyword | Neuron-specific enolase | - |
dc.subject.keyword | tuberculous meningitis | - |
dc.contributor.alternativeName | Kim, Won Joo | - |
dc.contributor.alternativeName | Song, Tae Jin | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.alternativeName | Choi, Young Chul | - |
dc.contributor.affiliatedAuthor | Kim, Won Joo | - |
dc.contributor.affiliatedAuthor | Song, Tae Jin | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Yul | - |
dc.contributor.affiliatedAuthor | Choi, Young Chul | - |
dc.citation.volume | 53 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1068 | - |
dc.citation.endPage | 1072 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.53(6) : 1068-1072, 2012 | - |
dc.identifier.rimsid | 29645 | - |
dc.type.rims | ART | - |
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