164 454

Cited 0 times in

Therapeutic effects of carbogen inhalation and lipo-prostaglandin E1 in sudden hearing loss

Authors
 Hyun-Jin Lee  ;  Chong Yoon Park  ;  Jae Heon Lee  ;  Hoon-Shik Yang  ;  Joo Hyun Kim  ;  Myung Jin Ban  ;  In Seok Moon 
Citation
 YONSEI MEDICAL JOURNAL, Vol.53(5) : 999-1004, 2012 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2012
MeSH
Administration, Inhalation ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alprostadil/administration & dosage ; Alprostadil/therapeutic use* ; Carbon Dioxide/administration & dosage ; Carbon Dioxide/therapeutic use* ; Female ; Hearing Loss, Sudden/drug therapy* ; Humans ; Male ; Middle Aged ; Oxygen/administration & dosage ; Oxygen/therapeutic use* ; Retrospective Studies ; Treatment Outcome ; Young Adult
Keywords
Sudden hearing loss ; lipo-prostaglandin E1 ; carbogen
Abstract
PURPOSE: Vascular disorders and viral infections are considered the main causes of sudden hearing loss (SHL), although its pathogenesis remain unclear. Treatments include carbogen inhalation and lipo-prostaglandin E1 (lipo-PGE1), both of which have circulation-enhancing effects. We investigated the effectiveness of carbogen inhalation and lipo-PGE1 in SHL.

MATERIALS AND METHODS: This retrospective review included 202 patients with idiopathic SHL who visited our clinic within 14 days of symptom onset between January 2006 and June 2010. All patients received oral prednisolone for 10 days. Of the 202 patients, 44 received no additional treatment, 106 received additional carbogen inhalation, and 52 received additional lipo-PGE1. Hearing improvement was measured using Siegel's criteria.

RESULTS: Overall recovery rates were 67.9% in the carbogen group, 53.8% in the lipo-PGE1 group, and 52.3% in the steroid-only control group (p=0.097). Limited to type 1 and type 2 categories of Sigels's criteria, the carbogen group had a significantly higher recovery rate (53.8%) than the lipo-PGE1 group (26.9%) and the steroid-only control group (38.6%) (p=0.005).

CONCLUSION: Carbogen inhalation added to steroid was a more effective treatment than lipo-PGE1 added to steroid or steroid alone in patients with SHL.
Files in This Item:
T201202800.pdf Download
DOI
22869484
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Moon, In Seok(문인석) ORCID logo https://orcid.org/0000-0002-3951-5074
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92120
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links