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A direct inhibitory effect of botulinum toxin type A on antral circular muscle contractility of guinea pig

Title
 A direct inhibitory effect of botulinum toxin type A on antral circular muscle contractility of guinea pig
Authors
 Jung Ho Park; EunJoo Choi; Yong Ho Lee; Hyojin Park
Issue Date
2012
Journal Title
 Yonsei Medical Journal
ISSN
 0513-5796
Citation
 Yonsei Medical Journal, Vol.53(5) : 968~973, 2012
Abstract
PURPOSE: Recent studies suggest new mechanisms of Botulinum toxin (BoNT) other than inhibiting acetylcholine (ACh) release from nerve terminals. The aim of this study was to determine whether other mechanisms for BoNT exist, so that it directly inhibits smooth muscle contraction. MATERIALS AND METHODS: Guinea pig antral muscle strips were studied in vitro after 2 hours of exposure to Botulinum toxin type A (BoNT/A). Contractile responses to electric field stimulation (EFS), high K(+) (60 mM) and ACh (100 μM) were evaluated 24 and 48 hours after antral intramuscular injection of BoNT/A or vehicle. RESULTS: BoNT/A inhibited muscular contraction caused by high K(+) and ACh. Contractile responses to low (1 and 4 Hz) and high (8 and 20 Hz) frequency EFS of antral muscle strips 24 and 48 hours after antral intramuscular injection of BoNT/A were significantly inhibited. CONCLUSION: The ability of BoNT/A to directly inhibit antral muscular contractility suggests a new mechanism for the pharmacologic actions of BoNT-direct inhibition of muscular contraction.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92109
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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