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Spontaneous bacterial peritonitis in patients with hepatitis B virus-related liver cirrhosis: community-acquired versus nosocomial

Authors
 Seung Up Kim  ;  Young Eun Chon  ;  Chun Kyon Lee  ;  Jun Yong Park  ;  Do Young Kim  ;  Kwang-Hyub Han  ;  Chae Yoon Chon  ;  Sinyoung Kim  ;  Kyu Sik Jung  ;  Sang Hoon Ahn 
Citation
 YONSEI MEDICAL JOURNAL, Vol.53(2) : 328-336, 2012 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2012
MeSH
Community-Acquired Infections/etiology ; Community-Acquired Infections/microbiology* ; Community-Acquired Infections/mortality ; Community-Acquired Infections/virology ; Female ; Hepatitis B virus/pathogenicity* ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/mortality ; Liver Cirrhosis/virology* ; Male ; Middle Aged ; Peritonitis/etiology ; Peritonitis/microbiology* ; Peritonitis/mortality ; Peritonitis/virology* ; Retrospective Studies
Keywords
Ascites ; cirrhosis ; community-acquired ; nosocomial ; spontaneous bacterial peritonitis
Abstract
PURPOSE: Spontaneous bacterial peritonitis (SBP) frequently develops in patients with liver cirrhosis; however, there is little data to suggest whether the acquisition site of infection influences the prognosis. This study compared the bacteriology, clinical characteristics and treatment outcomes of community-acquired SBP (CA-SBP) and nosocomial SBP (N-SBP).

MATERIALS AND METHODS: The medical records of 130 patients with hepatitis B virus (HBV)-related liver cirrhosis, who had experienced a first episode of SBP between January 1999 and December 2008, were reviewed.

RESULTS: The study population included 111 (85.4%) patients with CA-SBP and 19 (14.6%) patients with N-SBP. Baseline and microbiological characteristics as well as clinical course, including in-hospital mortality, did not differ between patients with CA-SBP and those with N-SBP (all p>0.05). The median survival time was 6.5 months, and 117 (90.0%) patients died during the follow-up period. Patients with CA-SBP and N-SBP survived for median periods of 6.6 and 6.2 months, respectively, without significant difference (p=0.569). Time to recurrence did not differ between patients with CA-SBP and N-SBP (4.7 vs. 3.6 months, p=0.925).

CONCLUSION: The acquisition site of infection did not affect clinical outcomes for patients with HBV-related liver cirrhosis who had experienced their first episode of SBP. Third-generation cephalosporins may be effective in empirically treating these patients, regardless of the acquisition site of the infection.
Files in This Item:
T201201922.pdf Download
DOI
22318820
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Chon, Young Eun(전영은)
Chon, Chae Yoon(전재윤)
Jung, Kyu Sik(정규식)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92099
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