Cited 7 times in

Pattern of distant recurrence according to the molecular subtypes in Korean women with breast cancer

Title
 Pattern of distant recurrence according to the molecular subtypes in Korean women with breast cancer 
Authors
 Hyung Seok Park ; Shinhyuk Kim ; Sang Seol Jung ; Byung Joo Song ; Ja Seong Bae ; Byung Joo Chae ; Ho Yoo ; Kiho Kim 
Issue Date
2012
Journal Title
 World Journal of Surgical Oncology 
ISSN
 1477-7819 
Citation
 World Journal of Surgical Oncology, Vol.10(4) : 1~7, 2012 
Abstract
BACKGROUND: Distant recurrence is one of the most important risk factors in overall survival, and distant recurrence is related to a complex biologic interaction of seed and soil factors. The aim of the study was to investigate the association between the molecular subtypes and patterns of distant recurrence in patients with breast cancer. METHODS: In an investigation of 313 women with breast cancer who underwent surgery from 1994 and 2000, the expressions of estrogen and progestrone receptor (ER/PR), and human epithelial receptor-2 (HER2) were evaluated. The subtypes were defined as luminal-A, luminal-HER2, HER2-enriched, and triple negative breast cancer (TNBC) according to ER, PR, and HER2 status. RESULTS: Bone was the most common site of distant recurrence. The incidence of first distant recurrence site was significantly different among the subtypes. Brain metastasis was more frequent in the luminal-HER2 and TNBC subtypes. In subgroup analysis, overall survival in patients with distant recurrence after 24 months after surgery was significantly different among the subtypes. CONCLUSIONS: Organ-specific metastasis may depend on the molecular subtype of breast cancer. Tailored strategies against distant metastasis concerning the molecular subtypes in breast cancer may be considered.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92040
DOI
10.1186/1477-7819-10-4
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T201206127.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse