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Accompanying renal injuries did not impact graft survival in patients with transplant glomerulopathy

Title
 Accompanying renal injuries did not impact graft survival in patients with transplant glomerulopathy
Authors
 B.J. Lim; D.J. Joo; H.J. Jeong; Y.S. Kim
Issue Date
2012
Journal Title
 Transplantation Proceedings
ISSN
 0041-1345
Citation
 Transplantation Proceedings, Vol.44(3) : 616~618, 2012
Abstract
Transplant glomerulopathy (TG) a morphological feature of chronic active antibody-mediated rejection, is associated with donor-specific antibody, peritubular capillary deposition of C4d, and multilayering of peritubular capillary basement membranes. To evaluate the significance of accompanying nonimmunologic injuries in TG, we retrospectively reviewed 2839 renal allograft cases at our institute among which TG was diagnosed in 81 patients (2.9%). Among TG cases, 48 samples showed accompanying diseases such as chronic calcineurin inhibitor toxicity, hepatitis viral infection, posttransplant diabetes, and glomerulonephritis. Comparing the pure form of TG with TG-mixed diseases, there was no difference in patient demography, serum creatinine values, and proteinuria. Among histological parameters, severe hyalinosis was more frequently observed among the TG plus other diseases group. The two groups did not show significant difference in graft survival (P = .216).
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91957
DOI
10.1016/j.transproceed.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0041134511017040
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