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Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: A multicenter open-label single-arm trial in Korean patients
DC Field | Value | Language |
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dc.contributor.author | 이병인 | - |
dc.contributor.author | 허경 | - |
dc.date.accessioned | 2014-12-19T17:40:01Z | - |
dc.date.available | 2014-12-19T17:40:01Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1059-1311 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91842 | - |
dc.description.abstract | OBJECTIVE: To evaluate the efficacy and safety of adjunctive zonisamide (ZNS) therapy in Korean adults with uncontrolled partial epilepsy. METHODS: Study patients had an average of at least one seizure per 4-week (averaged over a 12-week historical baseline) despite the use of one to three antiepileptic drugs. The starting dose of ZNS was 100mg/day, and was increased to 200mg/day after 2weeks. During the 12-week maintenance period, the dose of ZNS was adjusted to 200-400mg/day based on the physicians' discretion. The global evaluation scale (GES) and quality of life (QOLIE-31) were also evaluated. RESULTS: A total of 121 patients were enrolled, of which 88 patients completed the study. The median percent reduction in weekly seizure frequency over the treatment period was 59.0%. The ≥50% and ≥75% responder rates were 57.3% and 38.5%, respectively. Seizure freedom over the treatment period was observed in 25 patients, but seizure freedom throughout the 16-week treatment period was attained in only 16 patients. On investigator's GES, 84 patients were considered improved, with 33 patients showing marked improvement. In QOLIE-31 scale, seizure worry improved significantly but emotional well-being deteriorated. Treatment-emergent adverse events (AEs) were reported in 80 patients. The most common AEs were dizziness (28.1%), somnolence (24.0%), anorexia (18.2%), headache (14.0%), nausea (13.2%), and weight loss (10.7%). Twenty-two patients discontinued the trial due to drug-related AEs. CONCLUSIONS: Our results suggest that adjunctive ZNS therapy for the treatment of refractory partial epilepsy, though efficacious, is associated with significant tolerability problems. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anticonvulsants/administration & dosage* | - |
dc.subject.MESH | Anticonvulsants/adverse effects | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Epilepsies, Partial/drug therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Isoxazoles/administration & dosage* | - |
dc.subject.MESH | Isoxazoles/adverse effects | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Seizures/drug therapy* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: A multicenter open-label single-arm trial in Korean patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Kyoung Heo | - |
dc.contributor.googleauthor | Byung In Lee | - |
dc.contributor.googleauthor | Sang Do Yi | - |
dc.contributor.googleauthor | Yong Won Cho | - |
dc.contributor.googleauthor | Dong Jin Shin | - |
dc.contributor.googleauthor | Hong Ki Song | - |
dc.contributor.googleauthor | Ok Joon Kim | - |
dc.contributor.googleauthor | Sung-Pa Park | - |
dc.contributor.googleauthor | Sung Eun Kim | - |
dc.contributor.googleauthor | Sang Ho Kim | - |
dc.contributor.googleauthor | Jun Hong Lee | - |
dc.contributor.googleauthor | Kyu-Sik Kim | - |
dc.contributor.googleauthor | Se-Jin Lee | - |
dc.identifier.doi | 22226572 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02797 | - |
dc.contributor.localId | A04341 | - |
dc.relation.journalcode | J02648 | - |
dc.identifier.eissn | 1532-2688 | - |
dc.identifier.pmid | 22226572 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1059131111003177 | - |
dc.subject.keyword | Antiepileptic drugs | - |
dc.subject.keyword | Zonisamide | - |
dc.subject.keyword | Epilepsy | - |
dc.subject.keyword | Partial seizures | - |
dc.subject.keyword | Open-label study | - |
dc.subject.keyword | Add-on therapy | - |
dc.contributor.alternativeName | Lee, Byung In | - |
dc.contributor.alternativeName | Heo, Kyoung | - |
dc.contributor.affiliatedAuthor | Lee, Byung In | - |
dc.contributor.affiliatedAuthor | Heo, Kyoung | - |
dc.citation.volume | 21 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 188 | - |
dc.citation.endPage | 193 | - |
dc.identifier.bibliographicCitation | SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.21(3) : 188-193, 2012 | - |
dc.identifier.rimsid | 29951 | - |
dc.type.rims | ART | - |
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