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Elevated interleukin-32 expression in granulomatosis with polyangiitis

Title
Elevated interleukin-32 expression in granulomatosis with polyangiitis
Authors
Suyoung Bae;Yong-Gil Kim;Soohyun Kim;Eun Young Song;Yong-Beom Park;Bin Yoo;Chang-Keun Lee;Areum Kwak;Eusom Kim;Kwangwon Hong;Hyunjhung Jeon;Taebong Kang;Siyoung Lee;Jaewoo Hong;Jida Choi
Issue Date
2012
Journal Title
Rheumatology
ISSN
1462-0324
Citation
Rheumatology, Vol.51(11) : 1979~1988, 2012
Abstract
OBJECTIVE: To evaluate the role of IL-32 in granulomatosis with polyangiitis (GPA) patients and the relationship between IL-32 and disease activity, as PR3 has the ability to bind and activate IL-32, which has been described as a novel cytokine that induces inflammatory cytokines. METHODS: We investigated the level of IL-32, PR3, TNF-α and IL-6 in GPA patients by using ELISA. Northern blot was used to analyse the level of IL-32 mRNA in leucocytes of GPA patients. The intracellular colocalization of IL-32 and PR3 in leucocytes was examined by IF staining. RESULTS: We observed that IL-32 and PR3 levels in GPA patients were increased significantly when compared with normal individuals and each was tightly associated (P < 0.001). Northern blot analysis revealed that the mRNA level of IL-32 was prominently elevated in leucocytes of GPA patients. The intracellular colocalization of IL-32 and PR3 in leucocytes from GPA patients vs normal individuals was verified by IF staining. CONCLUSION: IL-32 level was elevated in GPA patients but its level was changed by treatment response. IL-32 could be an index in GPA and play a role in the aetiology of GPA.
URI
http://rheumatology.oxfordjournals.org/content/51/11/1979.long

http://ir.ymlib.yonsei.ac.kr/handle/22282913/91812
DOI
10.1093/rheumatology/kes163
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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