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Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis

Title
 Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis
Authors
 KYUNG-WOOK JO; KYEONGMAN JEON; TAE SUN SHIM; YONG IL HWANG; JAE CHOL CHOI; WON-IL CHOI; SANG BONG CHOI; JAE-JOON YIM; SEUNG HEON LEE; KWANG HA YOO; YEE HYUNG KIM; KYUNG CHAN KIM; WON-JUNG KOH; YOUNG AE KANG
Issue Date
2012
Journal Title
 Respirology
ISSN
 1323-7799
Citation
 Respirology, Vol.17(7) : 1125~1130, 2012
Abstract
BACKGROUND AND OBJECTIVE: The results of tuberculin skin tests (TST) and QuantiFERON TB-Gold In-Tube (QFT-GIT) assays were compared in close contacts of patients with multidrug-resistant tuberculosis (MDR-TB). METHODS: Close contacts of patients with bacteriologically confirmed MDR-TB (n = 101) were assessed. Most contacts were members of the households of patients, and 79 (78.2%) had received Bacille Calmette-Guerin (BCG) vaccination. Samples from each contact were tested using the TST and the QFT-GIT assay on the same day, and the concordance between these results was assessed using kappa (κ) coefficients. RESULTS: Forty-eight subjects (47.5%) showed positive responses on TST, using a 10-mm induration cut-off, and 54 (53.5%) were positive for the QFT-GIT assay. Of the 48 individuals who were TST positive, 34 (70.8%) were positive for the QFT-GIT assay. Of the 53 subjects who were TST negative, 33 (62.5%) were negative for the QFT-GIT assay. The overall agreement between the two tests (κ coefficient) was 0.33. The κ coefficient was higher in the 22 subjects who had not received BCG vaccination (κ = 0.48) than in the 79 subjects who had received BCG vaccination (κ = 0.29). CONCLUSION: The TST and QFT-GIT assays showed poor correlation in close contacts of patients with MDR-TB, especially those contacts who had received BCG vaccination.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91792
DOI
10.1111/j.1440-1843.2012.02218.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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