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Diabetes, body mass index and the excess risk of coronary heart disease, ischemic and hemorrhagic stroke in the Asia Pacific Cohort Studies Collaboration

Title
 Diabetes, body mass index and the excess risk of coronary heart disease, ischemic and hemorrhagic stroke in the Asia Pacific Cohort Studies Collaboration
Authors
 Yoshitaka Murakami; Rachel R. Huxley; Mark Woodward; Hyeon Chang Kim; Xianghua Fang; Rumi Tsukinoki; Tai-Hing Lam
Issue Date
2012
Journal Title
 Preventive Medicine
ISSN
 0091-7435
Citation
 Preventive Medicine, Vol.54(1) : 38~41, 2012
Abstract
OBJECTIVE: To examine the effects of diabetes on coronary heart disease, ischemic and hemorrhagic stroke and cardiovascular disease according to category of body mass index. METHODS: Data on 161,161 men and women from 31 cohorts (baseline years, 1966-99; mean follow-up, 2-24 years) from the Asia Pacific Cohort Studies Collaboration were analyzed using Cox regression, stratified by sex and study and adjusted for age, systolic blood pressure and smoking. Diabetes was self-reported in all but one study. Body mass index was divided into five categories according to the World Health Organization Asian criteria. RESULTS: The hazard ratio (diabetes v. not) for cardiovascular disease was 1.83 (95% confidence interval, 1.66-2.01). Across body mass index categories, this hazard ratio did not change significantly (p=0.19). Similar lack of difference across body mass index groups was found for coronary heart disease (p=0.33), ischemic stroke (p=0.97) and hemorrhagic stroke (p=0.98). CONCLUSIONS: Body mass index does not modify the effect of diabetes on major cardiovascular outcomes.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91748
DOI
10.1016/j.ypmed.2011.10.010
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Preventive Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0091743511004282
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