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The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization

Title
The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization
Authors
Young Seok Park;Young Joo Jeon;Nam Keun Kim;Dong-Seok Kim;Joong-Uhn Choi;Tae Gon Kim;Ok-Joon Kim;Won-Chan Kim;Hyun Sook Kim;In Bo Han;Seung-Hun Oh;Kyu Young Chae;Hyun Seok Kim
Issue Date
2012
Journal Title
PLoS One
ISSN
1932-6203
Citation
PLoS One, Vol.7(10) : e47158, 2012
Abstract
We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF -634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/91739
DOI
10.1371/journal.pone.0047158
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurosurgery
Yonsei Authors
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