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Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats

Title
Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats
Authors
Ji-Woong Jang;Jeong-Ho Yun;Kyoo-Sung Cho;Seong-Ho Choi;Chang-Sung Kim;Ui-Won Jung;Ju-Woong Jang;Kwang-Il Lee
Issue Date
2012
Journal Title
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
ISSN
1079-2104
Citation
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, Vol.113(4) : 480~487, 2012
Abstract
OBJECTIVE: The aim of the current study was to determine whether a hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) ratio of 20/80 impregnated with recombinant human bone morphogenetic protein (rhBMP-2) enhances new bone formation and to evaluate the dose-dependent response of rhBMP-2. STUDY DESIGN: Critical-sized calvarial defects were made in rats, and biphasic calcium phosphate (BCP) with different rhBMP-2 doses was loaded into rat calvarial defects. The animals were allowed to heal for either 2 or 8 weeks. RESULTS: The percentages of new bone after 2 and 8 weeks of healing were significantly greater in the rhBMP-2-treated groups (at all doses) than in the control groups. The percentage of remaining BCP was significantly lower at 8 weeks than at 2 weeks in all groups that included BCP. CONCLUSIONS: rhBMP-2 administered using a BCP carrier significantly induces new bone formation. A dose-dependent response was not shown in the present study.
URI
http://www.sciencedirect.com/science/article/pii/S1079210411002459

http://ir.ymlib.yonsei.ac.kr/handle/22282913/91614
DOI
10.1016/j.tripleo.2011.04.013
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Periodontology
Yonsei Authors
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