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Biomarker detection for the diagnosis of lymph node metastasis from oral squamous cell carcinoma

Authors
 김기열 ; 이귀연 ; 차인호 
Citation
 Oral Oncology, Vol.48(4) : 311~319, 2012 
Journal Title
 Oral Oncology 
ISSN
 1368-8375 
Issue Date
2012
Abstract
Lymph node metastasis is an important prognostic factor in oral squamous cell carcinoma. However, the lack of significant biomarkers for lymph node metastasis can cause patients to be inappropriately treated and produce a poor prognosis. Therefore, there is a need to identify gene sets that are associated with lymph node metastasis. In this study, we used three expression datasets obtained from a public database and selected candidate gene sets that were related with lymph node metastasis from two datasets and a combined dataset. We evaluated the selected gene set using OOB error rates in a validation dataset. The gene set detected from the combined dataset classified the lymph node status more accurately in the validation dataset and clear expression patterns classifying the lymph node status based on chromosomal location were observed. The combined dataset holds promise for use as a more accurate candidate gene set for the diagnosis of lymph node metastasis and the selected gene set could be used for biological validation in further studies.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91606
DOI
10.1016/j.oraloncology.2011.11.010
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 2. College of Dentistry > Dept. of Oral and Maxillofacial Surgery
1. 연구논문 > 5. Research Institutes > Oral Cancer Research Institute
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S1368837511008992
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