Cited 16 times in

Visceral fat thickness is associated with carotid atherosclerosis in peritoneal dialysis patients

Title
Visceral fat thickness is associated with carotid atherosclerosis in peritoneal dialysis patients
Authors
Mi Jung Lee;Dong Ho Shin;Tae-Hyun Yoo;Kyu Hun Choi;Shin-Wook Kang;Seung Hyeok Han;Jung Tak Park;Jwa-Kyung Kim;Dong Eun Yoo;Hyung Jung Oh;Seung Jun Kim
Issue Date
2012
Journal Title
Obesity
ISSN
1930-7381
Citation
Obesity, Vol.20(6) : 1301~1307, 2012
Abstract
Visceral fat has been known to associate with atherosclerosis, inflammation, and insulin resistance. However, the influence of visceral fat on cardiovascular disease (CVD) in peritoneal dialysis (PD) patients has never been elucidated. We investigated whether visceral fat thickness (VFT) has a predictive role in carotid atherosclerosis determined by carotid intima-media thickness (cIMT) in PD patients. A cross-sectional study was undertaken in 88 prevalent PD patients. BMI and waist circumference (WC) were measured as anthropometric indexes of obesity. VFT and subcutaneous fat thickness (SFT) were determined by sonographic measurement of abdominal fat. Carotid atherosclerosis was defined as increased cIMT (>1.0 mm) or presence of plaque. Thirty-two (36.3%) patients had carotid atherosclerosis. Patients with carotid atherosclerosis showed significantly higher VFT, BMI, and WC. In univariate logistic analysis, BMI, WC, and VFT except SFT were significant risk factors of carotid atherosclerosis. However, multivariate analysis revealed VFT was an independent factor associated with carotid atherosclerosis after adjusting for demographic, biochemical parameters, and anthropometric indexes (per 1 mm increase, odds ratio (OR) = 2.294, 95% confidence interval: 1.048-5.021, P = 0.038). When the patients were divided into three groups according to VFT, log high sensitivity C-reactive protein (hs-CRP), and homeostasis model assessment-insulin resistance (HOMA(IR)) were both higher in the third tertile compared to other tertiles. In conclusion, VFT, not SFT, is independently associated with carotid atherosclerosis in PD patients. Therefore sonographic measurement of VFT could be useful to stratify the risk of cardiovascular disease in PD patients.
URI
http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.245/abstract

http://ir.ymlib.yonsei.ac.kr/handle/22282913/91580
DOI
10.1038/oby.2011.245
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse