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Regulation of Wnt/β-catenin signaling by CCAAT/enhancer binding protein β during adipogenesis

Authors
 Sung Soo Chung ; Ji Seon Lee ; Kyong Soo Park ; Jae-Woo Kim ; Hak Mo Lee ; Hye Seung Jung ; Byung Yong Ahn ; Min Kim 
Citation
 Obesity, Vol.20(3) : 482~487, 2012 
Journal Title
 Obesity 
ISSN
 1930-7381 
Issue Date
2012
Abstract
Activation of the Wnt/β-catenin signaling pathway inhibits adipogenesis, while disruption of Wnt signaling leads to spontaneous adipogenesis. CCAAT/enhancer binding protein β (C/EBPβ) is rapidly induced in early stages of adipogenesis and is responsible for transcriptional induction of two major adipogenic transcription factors, peroxisome proliferator-activated receptor γ (PPARγ) and C/EBPα. In this study, we examined whether C/EBPβ is involved in the suppression of Wnt/β-catenin signaling during adipogenesis. Knockdown of C/EBPβ expression not only inhibited adipogenesis but also maintained active Wnt/β-catenin signaling, after addition of adipogenic inducers. In contrast, overexpression of C/EBPβ substantially inhibited Wnt signaling. Interestingly, our data showed that C/EBPβ is involved in the expression of Wnt10b, a major Wnt ligand in preadipocytes, even though C/EBPβ is not an essential factor to regulate Wnt10b expression during adipogenesis, and that C/EBPβ inhibits Wnt10b promoter activity by directly binding to specific regions of the promoter. These results suggest a dual function of C/EBPβ: stimulating expression of adipogenic genes and inhibiting Wnt signaling.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91579
DOI
10.1038/oby.2011.212
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biochemistry & Molecular Biology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.212/abstract
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