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Predicting long-term remission by measuring immediate postoperative growth hormone levels and oral glucose tolerance test in acromegaly
DC Field | Value | Language |
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dc.contributor.author | 김선호 | - |
dc.contributor.author | 김의현 | - |
dc.contributor.author | 오민철 | - |
dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2014-12-19T17:31:00Z | - |
dc.date.available | 2014-12-19T17:31:00Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0148-396X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91555 | - |
dc.description.abstract | BACKGROUND: The suppression of the growth hormone (GH) on an oral glucose tolerance test (OGTT) has been accepted as the most reliable parameter for determining remission of acromegaly. OBJECTIVE: To evaluate the role of immediate postoperative GH level and 1-week postoperative OGTT as early predictive tools of long-term surgical remission. METHODS: One hundred ninety-four acromegalic patients who received transsphenoidal tumor resection and were followed up for > 1.5 years (3.80 ± 0.17 years) with at least 3 postoperative OGTTs were evaluated. Level of GH was measured 2, 6, 12, 18, 24, 48, and 72 hours postoperatively, and an OGTT was performed 1 week after surgery, every 6 months for the first 3 years, and annually thereafter. RESULTS: One hundred seventy-seven patients underwent gross total resection; long-term remission was achieved in 153. The GH level at 24 hours after surgery showed the highest predictive power for long-term remission. Long-term remission was maintained in 125/127 (98.4%) patients who had nadir GH levels < 1.0 μg/L on an early postoperative OGTT. However, when nadir GH levels were > 1.0 μg/L on an early postoperative OGTT, long-term remission was observed in 28 patients (28 of 67, 41.8%) in a delayed fashion. One-week postoperative OGTT had a sensitivity of 81.7% and specificity of 95.1% for predicting remission. CONCLUSION: Immediate postoperative GH level is a very good predictor of long-term outcome in acromegaly. One-week postoperative OGTT is also a good predictor with high specificity. These findings may provide critical information for the determination of adjuvant treatment after surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NEUROSURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acromegaly/blood | - |
dc.subject.MESH | Acromegaly/diagnosis* | - |
dc.subject.MESH | Acromegaly/epidemiology | - |
dc.subject.MESH | Acromegaly/surgery* | - |
dc.subject.MESH | Adenoma/blood | - |
dc.subject.MESH | Adenoma/diagnosis | - |
dc.subject.MESH | Adenoma/epidemiology | - |
dc.subject.MESH | Adenoma/surgery | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Causality | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Glucose Tolerance Test/statistics & numerical data* | - |
dc.subject.MESH | Growth Hormone/blood* | - |
dc.subject.MESH | Growth Hormone-Secreting Pituitary Adenoma/blood | - |
dc.subject.MESH | Growth Hormone-Secreting Pituitary Adenoma/diagnosis* | - |
dc.subject.MESH | Growth Hormone-Secreting Pituitary Adenoma/epidemiology | - |
dc.subject.MESH | Growth Hormone-Secreting Pituitary Adenoma/surgery* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Postoperative Care/methods | - |
dc.subject.MESH | Postoperative Care/statistics & numerical data | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Remission Induction | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Predicting long-term remission by measuring immediate postoperative growth hormone levels and oral glucose tolerance test in acromegaly | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Kim, Eui Hyun | - |
dc.contributor.googleauthor | Oh, Min Chul | - |
dc.contributor.googleauthor | Lee, Eun Jig | - |
dc.contributor.googleauthor | Kim, Sun Ho | - |
dc.identifier.doi | 22067418 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00560 | - |
dc.contributor.localId | A00837 | - |
dc.contributor.localId | A02366 | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J02366 | - |
dc.identifier.eissn | 1524-4040 | - |
dc.identifier.pmid | 22067418 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006123-201205000-00007&LSLINK=80&D=ovft | - |
dc.subject.keyword | Acromegaly | - |
dc.subject.keyword | Growth hormone | - |
dc.subject.keyword | Oral glucose tolerance test | - |
dc.subject.keyword | Remission | - |
dc.subject.keyword | Transsphenoidal approach | - |
dc.contributor.alternativeName | Kim, Sun Ho | - |
dc.contributor.alternativeName | Kim, Eui Hyun | - |
dc.contributor.alternativeName | Oh, Min Chul | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Kim, Sun Ho | - |
dc.contributor.affiliatedAuthor | Kim, Eui Hyun | - |
dc.contributor.affiliatedAuthor | Oh, Min Chul | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.citation.volume | 70 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1106 | - |
dc.citation.endPage | 1113 | - |
dc.identifier.bibliographicCitation | NEUROSURGERY, Vol.70(5) : 1106-1113, 2012 | - |
dc.identifier.rimsid | 29301 | - |
dc.type.rims | ART | - |
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