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Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress

Authors
 Yeong Shin Yim ; Jinu Lee ; Dong Goo Kim ; Chul Hoon Kim ; Teresa Song ; Gun-Tae Kim 
Citation
 Neuroscience Letters, Vol.519(1) : 62~66, 2012 
Journal Title
 Neuroscience Letters 
ISSN
 0304-3940 
Issue Date
2012
Abstract
An individual's behavior is generally based on genetic blueprint and previous experiences. A coping strategy, affected by personal interpretation of past events, can be determined by behavioral controllability of stress. In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress. Rats were exposed to stress via inescapable and unpredictable footshocks on PNDs 14 and 90. Coping strategies to stress were also measured. Hippocampal mGluR5 was found to be linked to the behavioral coping strategy, as it increased in rats that showed helplessness behavior (HL (+) group) and decreased in those that did not (HL (-) group). Also, the HL (+) group showed a lack of adaptation in a novel environment but the HL (-) group did not. The results suggest that mGluR5 has a pivotal role in the controllability-based coping strategy. Hippocampal mGluR5 could be a target molecule in the manipulation of neuropsychiatric conditions for which maladaptation is a part of behavioral consequences.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91549
DOI
10.1016/j.neulet.2012.05.022
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pharmacology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0304394012006581
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