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Transplantation of an adipose stem cell cluster in a spinal cord injury

Title
 Transplantation of an adipose stem cell cluster in a spinal cord injury
Authors
 Oh, Jin Soo; Park, In Su; Ha, Yoon; Kim, Sang-Heon; Yoon, Do Heum; Kim, Keung Nyun
Issue Date
2012
Journal Title
 Neuroreport
ISSN
 0959-4965
Citation
 Neuroreport, Vol.23(5) : 277~282, 2012
Abstract
We investigated whether transplantation of a three-dimensional cell mass of adipose-derived stem cells (3DCM-ASCs) improved hind limb functional recovery by the stimulation of angiogenesis and neurogenesis in a spinal cord injury. In in-vitro experiments, we confirmed that 3DCM-ASCs differentiated into CD31-positive endothelial cells. To evaluate the therapeutic effect of 3DCM-ASCs in vivo, PBS, human adipose tissue-derived stem cells, and 3DCM-ASCs were transplanted into a spinal cord injury model. The 3DCM-ASCs transplanted into the injured spinal cord differentiated into CD31-positive endothelial cells and remained differentiated. Transplantation of 3DCM-ASCs into the injured spinal cord significantly elevated the density of vascular formations through angiogenic factors released by the 3DCM-ASCs at the lesion site, and enhanced axonal outgrowth at the lesion site. Consistent with these results, the transplantation of 3DCM-ASCs significantly improved functional recovery compared with both ASC transplantation and PBS treatment. These findings suggest that transplantation of 3DCM-ASCs may be an effective stem cell therapy for the treatment of spinal cord injuries and neural ischemia.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91543
DOI
10.1097/WNR.0b013e3283505ae2
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurosurgery
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
Yonsei Authors
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Link
 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201203280-00003&LSLINK=80&D=ovft
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