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Neuroimaging of Wernicke's encephalopathy and Korsakoff's syndrome

Authors
 Young-Chul Jung ; Sandra Chanraud ; Edith V. Sullivan 
Citation
 Neuropsychology Review, Vol.22(2) : 170~180, 2012 
Journal Title
 Neuropsychology Review 
ISSN
 1040-7308 
Issue Date
2012
Abstract
There is considerable evidence that neuroimaging findings can improve the early diagnosis of Wernicke's encephalopathy (WE) in clinical settings. The most distinctive neuroimaging finding of acute WE are cytotoxic edema and vasogenic edema, which are represented by bilateral symmetric hyperintensity alterations on T2-weighted MR images in the periphery of the third ventricle, periaqueductal area, mammillary bodies and midbrain tectal plate. An initial bout of WE can result in Korsakoff's syndrome (KS), but repeated bouts in conjunction with its typical comorbidity, chronic alcoholism, can result in signs of tissue degeneration in vulnerable brain regions. Chronic abnormalities identified with neuroimaging enable examination of brain damage in living patients with KS and have expanded the understanding of the neuropsychological deficits resulting from thiamine deficiency, alcohol neurotoxicity, and their comorbidity. Brain structure and functional studies indicate that the interactions involving the thalamus, mammillary bodies, hippocampus, frontal lobes, and cerebellum are crucial for memory formation and executive functions, and the interruption of these circuits by WE and chronic alcoholism can contribute substantially to the neuropsychological deficits in KS.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91537
DOI
10.1007/s11065-012-9203-4
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Psychiatry
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs11065-012-9203-4
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