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Thalamocortical inputs show post-critical-period plasticity

Authors
 Xin Yu ; Seungsoo Chung ; Alan P. Koretsky ; John T.R. Isaac ; Judith R. Walters ; Stephen J. Dodd ; Shumin Wang ; Der-Yow Chen 
Citation
 Neuron, Vol.74(4) : 731~742, 2012 
Journal Title
 Neuron 
ISSN
 0896-6273 
Issue Date
2012
Abstract
Experience-dependent plasticity in the adult brain has clinical potential for functional rehabilitation following central and peripheral nerve injuries. Here, plasticity induced by unilateral infraorbital (IO) nerve resection in 4-week-old rats was mapped using MRI and synaptic mechanisms were elucidated by slice electrophysiology. Functional MRI demonstrates a cortical potentiation compared to thalamus 2 weeks after IO nerve resection. Tracing thalamocortical (TC) projections with manganese-enhanced MRI revealed circuit changes in the spared layer 4 (L4) barrel cortex. Brain slice electrophysiology revealed TC input strengthening onto L4 stellate cells due to an increase in postsynaptic strength and the number of functional synapses. This work shows that the TC input is a site for robust plasticity after the end of the previously defined critical period for this input. Thus, TC inputs may represent a major site for adult plasticity in contrast to the consensus that adult plasticity mainly occurs at cortico-cortical connections.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91534
DOI
10.1016/j.neuron.2012.04.024
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0896627312003923
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