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Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres

Authors
 Eugene Lee ; Yoochan Hong ; Jaemoon Yang ; Yong-Min Huh ; Jin-Suck Suh ; Seungjoo Haam ; Jihye Choi 
Citation
 Nanotechnology, Vol.23(46) : 465101, 2012 
Journal Title
 Nanotechnology 
ISSN
 0957-4484 
Issue Date
2012
Abstract
Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods, which strongly absorb near infrared light and increase local temperature, we effectively targeted and photo-ablated atypical cells. This biomarker-specific photothermal ablation model, using a smart nanoplatform, is a promising new strategy for selectively killing cancer cells, while sparing normal tissues.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91493
DOI
10.1088/0957-4484/23/46/465101
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
Yonsei Authors
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Link
 http://iopscience.iop.org/0957-4484/23/46/465101/
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