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Combined treatment of 3-hydroxyflavone and imatinib mesylate increases apoptotic cell death of imatinib mesylate-resistant leukemia cells

Title
Combined treatment of 3-hydroxyflavone and imatinib mesylate increases apoptotic cell death of imatinib mesylate-resistant leukemia cells
Authors
Jung-Hyun Kim;Minjung Song;Ssang-Goo Cho;Bon-Nyeo Koo;Youngsoo Kim;Jin-Hoi Kim;Chung Lee;Hye-Yeon Choi;Eung-Ryoung Lee;Geun-Ho Kang
Issue Date
2012
Journal Title
Leukemia Research
ISSN
0145-2126
Citation
Leukemia Research, Vol.36(9) : 1157~1164, 2012
Abstract
Imatinib mesylate, a Bcr/Abl tyrosine kinase inhibitor, is widely used in treating chronic myeloid leukemia. However, drug-resistance of leukemia cells becomes an emergent problem. Herein, various flavonoids were screened for applicability in leukemia treatment, and 3-hydroxyflavone (3-HF) was found to be most effective in reducing cancer cell viability. The combination of 3-HF and imatinib mesylate resulted in significant apoptotic cell death in imatinib mesylate-resistant leukemia cells. Combined treatment resulted in apparent activation of caspases and decrease of the oncoprotein phosphor-Bcr/Abl in leukemia cells. Our results suggest that this combined treatment is beneficial in imatinib mesylate-resistant chronic myelogenous leukemia.
URI
http://www.sciencedirect.com/science/article/pii/S0145212612002433

http://ir.ymlib.yonsei.ac.kr/handle/22282913/91401
DOI
10.1016/j.leukres.2012.05.018
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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