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Non-bacterial infections in Asian patients treated with alemtuzumab:a retrospective study of the Asian Lymphoma Study Group

Authors
 Seok Jin Kim ; Joon Ho Moon ; Yok Lam Kwong ; Won Seog Kim ; Ann-Lii Cheng ; Soon Thye Lim ; Arry Harryanto Reksodiputro ; Jong Ho Won ; Je Jung Lee ; Jae Yong Kwak ; Surapol Issaragrisil ; Tanin Intragumtornchai ; Yu Yan Hwang ; Jin Seok Kim ; Hawk Kim 
Citation
 Leukemia & Lymphoma, Vol.53(8) : 1515~1524, 2012 
Journal Title
 Leukemia & Lymphoma 
ISSN
 1042-8194 
Issue Date
2012
Abstract
This retrospective study concerns non-bacterial infections in Asian patients receiving alemtuzumab. The clinical data of 182 patients treated with alemtuzumab alone or alemtuzumab-containing chemotherapy between the years 2003 and 2009 was collected from six Asian countries. Alemtuzumab was used in the setting of frontline (n =48) or salvage (n =90) treatment, and as a part of the conditioning regimen for allogeneic stem cell transplant (n =44). Reactivation of cytomegalovirus (66/182) and varicella zoster virus (25/182), and fungal infection (31/182) including invasive pulmonary aspergillosis, were the most common infectious complications in this retrospective analysis. Thus, we recommend routine prophylaxis with valganciclovir and itraconazole, especially when alemtuzumab is used in the conditioning regimen for allogeneic stem cell transplant. Pneumocystis jirovecii pneumonia (PJP) was found in four patients (3%, 4/122) receiving alemtuzumab as conditioning for stem cell transplant or salvage treatment. Three cases of hepatitis B virus reactivation were found in antigen-negative patients, and 16 cases of tuberculosis were observed. Infection is the major complication of alemtuzumab therapy, and these infectious complications are potentially severe and life-threatening. Based on our retrospective analysis, we have constructed a guideline for antimicrobial prophylaxis in Asian patients receiving alemtuzumab therapy.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91393
DOI
10.3109/10428194.2012.659735
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://informahealthcare.com/doi/abs/10.3109/10428194.2012.659735
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