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급성 호흡기 감염으로 입원한 소아에서 분리된 보카바이러스의 계통분석

Title
 급성 호흡기 감염으로 입원한 소아에서 분리된 보카바이러스의 계통분석 
Other Titles
 Phylogenetic Analysis of Human Bocavirus in Hospitalized Children with Acute Respiratory Tract Infection in Korea 
Authors
 안종균 ; 최성열 ; 김기환 ; 김동수 
Issue Date
2012
Journal Title
 Korean Journal of Pediatric Infectious Diseases (소아감염) 
ISSN
 1226-3923 
Citation
 Korean Journal of Pediatric Infectious Diseases (소아감염), Vol.19(2) : 71~78, 2012 
Abstract
Purpose: Human bocavirus (hBoV), a recently discovered virus, has been detected in children with respiratory tract infections worldwide. The aim of this study was to analyze the frequency and molecular phylogeny of hBoV in the respiratory samples of children with acute respiratory tract infections in 2010. Methods: Nasopharyngeal samples were collected from 953 children with lower respiratory tract infections at Severance children’s hospital in Korea from January 2010 to December 2010. We applied the multiplex PCR technique for the identification of 12 respiratory viruses from the samples. Among the total specimens, hBoV positive samples were subjected to phylogenetic analysis by sequencing a fragment of the VP1/VP2 gene junction. Results: hBoV was detected in 141 (14.8%) among 953 patients. The 61.7% of hBoV-positive samples were found to co-exist with other respiratory viruses. The results of phylogenetic analysis showed that all 141 hBoV-positive isolates were identified as hBoV 1, revealing a high similarity among the isolates (>98%). Conclusion: hBoV 1 with minimal sequence variations circulated in children with acute respiratory infections during 2010. More research is needed to determine the clinical severity and outcomes of the minimal sequence variations.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91322
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
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