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Effect of sevoflurane on grafted kidney function in renal transplantation.

Title
Effect of sevoflurane on grafted kidney function in renal transplantation.
Authors
Jin Ha Park;Jae Hoon Lee;Bon-Nyeo Koo;Yu Seun Kim;Ki Jun Song;Dong Jin Joo
Issue Date
2012
Journal Title
Korean Journal of Anesthesiology
ISSN
2005-6419
Citation
Korean Journal of Anesthesiology, Vol.62(6) : 529~535, 2012
Abstract
BACKGROUND: The objective of this retrospective study was to determine if there are any differences in grafted kidney function in recipients of kidney transplantation (KT) when donors and recipients were anesthetized with sevoflurane compared to desflurane. METHODS: Seventy-three pairs of donors-recipients were anesthetized with sevoflurane (Sevo group) and 71 pairs were anesthetized with desflurane (Des group). We retrospectively investigated the blood urea nitrogen (BUN) levels, creatinine (Cr) levels, and estimated glomerular filtration rates (eGFR) of the recipients in both groups for 1 year postoperatively. We tested non-inferiority for serum creatinine at discharge and 1 year after KT. Short-term (1 year) outcomes of KT were assessed by the incidence of delayed graft function (DGF), acute rejection episodes (ARE), and graft failure. RESULTS: There were no differences in BUN, Cr, eGFR, or outcomes of KT at 1 year postoperatively. Specifically, the 95% confidence interval for the difference in creatinine levels between the Sevo and Des groups was less than the margin of equivalence at the time of discharge and 1 year after surgery. The occurrences of DGF, ARE, and graft failure were comparable between the groups. CONCLUSIONS: Compared to desflurane, sevoflurane had no adverse effects on grafted renal function or on the short-term outcome of renal transplantation.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/91231
DOI
10.4097/kjae.2012.62.6.529
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Biostatistics
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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