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Enhancement of anti-inflammatory and antinociceptive actions of red ginseng extract by fermentation

Title
 Enhancement of anti-inflammatory and antinociceptive actions of red ginseng extract by fermentation 
Authors
 Hyun-Joo Jung ; Hojin Choi ; Chang-Jin Lim ; Eun-Hee Park ; Jong Eun Lee ; Bin Kwon ; Hacksoo Kim ; Daehyun Shin ; Hye-Won Lim 
Issue Date
2012
Journal Title
 Journal of Pharmacy and Pharmacology 
ISSN
 0022-3573 
Citation
 Journal of Pharmacy and Pharmacology, Vol.64(5) : 756~762, 2012 
Abstract
OBJECTIVES: This work aimed to compare some pharmacological properties of red ginseng extract (RG) and fermented red ginseng extract (FRG). METHODS: Antinociceptive activity was analysed using the acetic acid-induced abdominal constriction response. Anti-inflammatory activity was evaluated using acetic acid-induced vascular permeability and carrageenan-induced inflammation in the air pouch, and analysed through the measurement of nitrite content in the lipopolysaccharide (LPS)-stimulated macrophage cells. Anti-angiogenic activity was determined using the chick chorioallantoic membrane assay. KEY FINDINGS: In-vivo anti-inflammatory activity of FRG was stronger than that of RG in two animal models, vascular permeability and air-pouch models. In the vascular permeability model, the doses of RG and FRG required for half-maximal inhibition (IC50) were 181 and 59mg/kg, respectively. FRG exhibited significantly stronger antinociceptive activity than RG. In the acetic acid-induced abdominal constriction response, the IC50 values of RG and FRG were 153 and 27mg/kg, respectively. Although both RG and FRG were able to suppress production of nitric oxide in the LPS-stimulated RAW264.7 macrophage cells, the suppressive activity of FRG appeared to be stronger than that of RG. However, RG and FRG showed similar anti-angiogenic activity. CONCLUSIONS: FRG possesses enhanced anti-inflammatory and antinociceptive activity but similar anti-angiogenic activity than RG.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91060
DOI
10.1111/j.2042-7158.2012.01460.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anatomy
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.2042-7158.2012.01460.x/abstract
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