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Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study.

Authors
 Jung-Chul Park ; Jong-Bin Lee ; Chang-Sung Kim ; Byung-Soo Kim ; Gun-Il Im ; Kyoo-Sung Cho ; Sang-Yeop Oh ; Guy Daculsi 
Citation
 Journal of Periodontal & Implant Science (JPIS), Vol.42(4) : 136~143, 2012 
Journal Title
 Journal of Periodontal & Implant Science (JPIS) 
ISSN
 2093-2278 
Issue Date
2012
Abstract
PURPOSE: The osseointegration around titanium mini-implants installed in macroporous biphasic calcium phosphate (MBCP) blocks was evaluated after incubation with recombinant human bone morphogenetic protein-2 (rhBMP-2) in an ectopic subcutaneous rat model. METHODS: Mini-implants (φ1.8×12 mm) were installed in MBCP blocks (bMBCPs, 4×5×15 mm) loaded with rhBMP-2 at 0.1 mg/mL, and then implanted for 8 weeks into subcutaneous pockets of male Sprague-Dawley rats (n=10). A histomorphometric analysis was performed, and the bone-to-implant contact (BIC) and bone density were evaluated. RESULTS: Significant osteoinductive activity was induced in the rhBMP-2/bMBCP group. The percentage of BIC was 41.23±4.13% (mean±standard deviation), while bone density was 33.47±5.73%. In contrast, no bone formation was observed in the bMBCP only group. CONCLUSIONS: This model represents a more standardized tool for analyzing osseointegration and bone healing along the implant surface and in bMBCPs that excludes various healing factors derived from selected animals and defect models.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91050
DOI
10.5051/jpis.2012.42.4.136
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Periodontology
Yonsei Authors
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