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Psychological and behavioral effects of chloral hydrate in day-case pediatric surgery: a randomized, observer-blinded study

Title
Psychological and behavioral effects of chloral hydrate in day-case pediatric surgery: a randomized, observer-blinded study
Authors
Hae K. Kil;Won O. Kim;Jeong-Yeon Hong;Aerina Lee;Youngjun Kwon;Sang W. Han
Issue Date
2012
Journal Title
Journal of Pediatric Surgery
ISSN
0022-3468
Citation
Journal of Pediatric Surgery, Vol.47(8) : 1592~1599, 2012
Abstract
BACKGROUND/PURPOSE: This prospective, randomized, and observer-blinded study was performed to evaluate the effects of oral chloral hydrate on perioperative psychological and behavioral phenomena in children. METHODS: In total, 100 boys (age, 1-5 years) scheduled for day-case unilateral orchiopexy were randomly allocated into 2 groups and orally administered either 40 mg/kg of chloral hydrate (CH group) or placebo (control group) 30 minutes before surgery, followed by assessment of anxiety, induction compliance, emergence delirium, postoperative pain, and maladaptive behavioral changes. RESULTS: Anxiety scores were significantly lower in the CH group compared with the control group (45.7 vs 28.8). The induction compliance of the CH group was better than that of the control group (3.2 vs 4.8). Postoperative sedation was more frequent (62.7% vs 20.4%); however, the incidence of vomiting was lower (2.0% vs 14.3%) in the CH group than in the control group. Postoperative emergence delirium and maladaptive behavior changes were similar between the 2 groups. CONCLUSION: Decreasing preoperative anxiety with oral chloral hydrate improves induction compliance and reduces postoperative pain intensity without delaying recovery in young boys. However, chloral hydrate had little impact on emergence delirium and postoperative maladaptive behavior.
URI
http://www.sciencedirect.com/science/article/pii/S0022346812000036

http://ir.ymlib.yonsei.ac.kr/handle/22282913/91036
DOI
10.1016/j.jpedsurg.2011.12.025
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Urology
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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