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Pre-treatment diagnosis of endometrial cancer through a combination of CA125 and multiplication of neutrophil and monocyte

Authors
 Bo Wook Kim  ;  Young Eun Jeon  ;  Hanbyoul Cho  ;  Eun Ji Nam  ;  Sang Wun Kim  ;  Sunghoon Kim  ;  Young Tae Kim  ;  Jae-Hoon Kim 
Citation
 JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, Vol.38(1) : 48-56, 2012 
Journal Title
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
ISSN
 1341-8076 
Issue Date
2012
MeSH
Biomarkers, Tumor/blood ; CA-125 Antigen/blood* ; Endometrial Neoplasms/blood ; Endometrial Neoplasms/diagnosis* ; Female ; Humans ; Leukocyte Count ; Membrane Proteins/blood* ; Middle Aged ; Monocytes* ; Neutrophils* ; Retrospective Studies ; Sensitivity and Specificity
Keywords
Biomarkers, Tumor/blood ; CA-125 Antigen/blood* ; Endometrial Neoplasms/blood ; Endometrial Neoplasms/diagnosis* ; Female ; Humans ; Leukocyte Count ; Membrane Proteins/blood* ; Middle Aged ; Monocytes* ; Neutrophils* ; Retrospective Studies ; Sensitivity and Specificity
Abstract
AIM:  This study aimed to investigate the clinical value of pre-treatment leukocyte differential counts and the prediction of endometrial cancer using leukocyte markers.

MATERIAL AND METHODS: Medical records of 238 women with pathologically confirmed endometrial cancer between March 2000 and June 2009 at two Korean hospitals were reviewed and compared to 596 healthy people visiting the Health Promotion Center in Gangnam Severance Hospital. For all study subjects, leukocyte differential counts and CA125 levels in serum obtained prior to operation were recorded. Multiplication of neutrophil and monocyte (MNM) was determined by multiplying neutrophil and monocyte counts then dividing by 10000. Differences between endometrial cancer patients and healthy controls were compared. The sensitivity and specificity for each marker as well as the combined use of CA125 and other leukocyte markers were assessed using receiver operating characteristic curves.

RESULTS: Mean white blood cell (WBC) counts were 6676 (6440-6913) cells/µL in endometrial cancer patients compared to 5663 (5542-5784) cells/µL in healthy controls (P<0.001). The area under curve (AUC) for CA125 was 0.689 with a sensitivity of 49.13% and specificity of 83.1% using an optimal cut-off value of 18.7U/mL. The AUC for MNM was 0.696 with a sensitivity of 62.9% and specificity of 69.1%. The combination of CA125 and MNM showed a higher AUC of 0.760 than use of CA125 or MNM alone.

CONCLUSION: The combination of MNM and CA125 is a simple and cost-effective method for predicting endometrial cancer.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1447-0756.2011.01694.x/abstract
DOI
22142582
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Bo Wook(김보욱)
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Nam, Eun Ji(남은지) ORCID logo https://orcid.org/0000-0003-0189-3560
Jeon, Young Eun(전영은)
Cho, Hanbyoul(조한별) ORCID logo https://orcid.org/0000-0002-6177-1648
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91020
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