Cited 0 times in

Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat

Title
 Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat 
Authors
 Hyo Jeong Kim ; Shin Hye Kim ; Hoon-Chul Kang ; Jin Sung Lee ; Kyo Yeon Koo ; Young-Mock Lee ; Joon Soo Lee ; Heung Dong Kim 
Issue Date
2012
Journal Title
 Journal of NeuroVirology 
ISSN
 1355-0284 
Citation
 Journal of NeuroVirology, Vol.18(2) : 81~90, 2012 
Abstract
Since HIV-1 Tat has been associated with neurocognitive dysfunction, we investigated 60 HIV-1 subtype B-infected individuals who were characterized for neurocognitive functioning and had paired CSF and blood plasma samples available. To avoid issues with repeated sampling, we generated population-based HIV-1 tat sequences from each compartment and evaluated these data using a battery of phylogenetic, statistical, and machine learning tools. These analyses identified position HXB2 5905 within the cysteine-rich domain of tat as a signature of CSF-derived HIV-1, and a higher number of mixed bases in CSF, as measure of diversity, was associated with HIV-associated neurocognitive disorder. Since identified mutations were synonymous, we evaluated the predicted secondary RNA structures, which showed that this mutation altered secondary structure. As a measure of divergence, the genetic distance between the blood and CSF-derived tat was inversely correlated with current and nadir CD4+ T cell counts. These data suggest that specific HIV-1 features of tat influence neurotropism and neurocognitive impairment.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91010
DOI
10.3349/ymj.2012.53.3.495
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T201201654.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse