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Dense deposit disease in Korean children: a multicenter clinicopathologic study

Title
Dense deposit disease in Korean children: a multicenter clinicopathologic study
Authors
Se Jin Park;Yong-Jin Kim;Jae Il Shin;Woo Yeong Chung;Kyo Sun Kim;Pyung Kil Kim;Dae Yeol Lee;Yong Hoon Park;Hyeon Joo Jeong;Beom Jin Lim;Tae-Sun Ha
Issue Date
2012
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934
Citation
Journal of Korean Medical Science, Vol.27(10) : 1215~1221, 2012
Abstract
The purpose of this study was to investigate the clinical, laboratory, and pathologic characteristics of dense deposit disease (DDD) in Korean children and to determine whether these characteristics differ between Korean and American children with DDD. In 2010, we sent a structured protocol about DDD to pediatric nephrologists throughout Korea. The data collected were compared with previously published data on 14 American children with DDD. Korean children had lower 24-hr urine protein excretion and higher serum albumin levels than American children. The light microscopic findings revealed that a higher percentage of Korean children had membranoproliferative glomerulonephritis patterns (Korean, 77.8%; American, 28.6%, P = 0.036), whereas a higher percentage of American children had crescents (Korean, 0%; American, 78.6%, P < 0.001). The findings from the electron microscopy revealed that Korean children were more likely to have segmental electron dense deposits in the lamina densa of the glomerular basement membrane (Korean, 100%; American, 28.6%, P = 0.002); mesangial deposit was more frequent in American children (Korean, 66.7%; American, 100%, P = 0.047). The histological findings revealed that Korean children with DDD were more likely to show membranoproliferative glomerulonephritis patterns than American children. The degree of proteinuria and hypoalbuminemia was milder in Korean children than American children.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/90906
DOI
10.3346/jkms.2012.27.10.1215
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
Yonsei Authors
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