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Nanog signaling in cancer promotes stem-like phenotype and immune evasion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 조한별 | - |
dc.date.accessioned | 2014-12-19T17:03:12Z | - |
dc.date.available | 2014-12-19T17:03:12Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0021-9738 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90688 | - |
dc.description.abstract | Adaptation of tumor cells to the host is a major cause of cancer progression, failure of therapy, and ultimately death. Immune selection drives this adaptation in human cancer by enriching tumor cells with a cancer stem cell-like (CSC-like) phenotype that makes them resistant to CTL-mediated apoptosis; however, the mechanisms that mediate CSC maintenance and proliferation are largely unknown. Here, we report that CTL-mediated immune selection drives the evolution of tumor cells toward a CSC-like phenotype and that the CSC-like phenotype arises through the Akt signaling pathway via transcriptional induction of Tcl1a by Nanog. Furthermore, we found that hyperactivation of the Nanog/Tcl1a/Akt signaling axis was conserved across multiple types of human cancer. Inhibition of Nanog in a murine model of colon cancer rendered tumor cells susceptible to immune-mediated clearance and led to successful, long-term control of the disease. Our findings establish a firm link among immune selection, disease progression, and the development of a stem-like tumor phenotype in human cancer and implicate the Nanog/Tcl1a/Akt pathway as a central molecular target in this process. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/genetics | - |
dc.subject.MESH | Apoptosis/immunology | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/metabolism | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/pathology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Colonic Neoplasms/genetics | - |
dc.subject.MESH | Colonic Neoplasms/immunology* | - |
dc.subject.MESH | Colonic Neoplasms/metabolism | - |
dc.subject.MESH | Colonic Neoplasms/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Homeodomain Proteins/genetics | - |
dc.subject.MESH | Homeodomain Proteins/immunology* | - |
dc.subject.MESH | Homeodomain Proteins/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred NOD | - |
dc.subject.MESH | Mice, SCID | - |
dc.subject.MESH | Nanog Homeobox Protein | - |
dc.subject.MESH | Neoplasm Transplantation | - |
dc.subject.MESH | Neoplastic Stem Cells/immunology | - |
dc.subject.MESH | Neoplastic Stem Cells/metabolism* | - |
dc.subject.MESH | Proto-Oncogene Proteins/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins/immunology | - |
dc.subject.MESH | Proto-Oncogene Proteins/metabolism | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/immunology | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.MESH | Signal Transduction/genetics | - |
dc.subject.MESH | Signal Transduction/immunology* | - |
dc.subject.MESH | Transcription, Genetic/genetics | - |
dc.subject.MESH | Transcription, Genetic/immunology | - |
dc.subject.MESH | Transplantation, Heterologous | - |
dc.subject.MESH | Tumor Escape* | - |
dc.title | Nanog signaling in cancer promotes stem-like phenotype and immune evasion | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Kyung Hee Noh | - |
dc.contributor.googleauthor | Bo Wook Kim | - |
dc.contributor.googleauthor | Kwon-Ho Song | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Young-Ho Lee | - |
dc.contributor.googleauthor | Jin Hee Kim | - |
dc.contributor.googleauthor | Joon-Yong Chung | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.contributor.googleauthor | Stephen M. Hewitt | - |
dc.contributor.googleauthor | Seung-Yong Seong | - |
dc.contributor.googleauthor | Chih-Ping Mao | - |
dc.contributor.googleauthor | T.-C. Wu | - |
dc.contributor.googleauthor | Tae Woo Kim | - |
dc.identifier.doi | 23093782 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A03921 | - |
dc.relation.journalcode | J01322 | - |
dc.identifier.eissn | 1558-8238 | - |
dc.identifier.pmid | 23093782 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Apoptosis/genetics | - |
dc.subject.keyword | Apoptosis/immunology | - |
dc.subject.keyword | CD8-Positive T-Lymphocytes/immunology | - |
dc.subject.keyword | CD8-Positive T-Lymphocytes/metabolism | - |
dc.subject.keyword | CD8-Positive T-Lymphocytes/pathology | - |
dc.subject.keyword | Cell Line, Tumor | - |
dc.subject.keyword | Cell Proliferation | - |
dc.subject.keyword | Colonic Neoplasms/genetics | - |
dc.subject.keyword | Colonic Neoplasms/immunology* | - |
dc.subject.keyword | Colonic Neoplasms/metabolism | - |
dc.subject.keyword | Colonic Neoplasms/pathology | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Homeodomain Proteins/genetics | - |
dc.subject.keyword | Homeodomain Proteins/immunology* | - |
dc.subject.keyword | Homeodomain Proteins/metabolism | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Inbred NOD | - |
dc.subject.keyword | Mice, SCID | - |
dc.subject.keyword | Nanog Homeobox Protein | - |
dc.subject.keyword | Neoplasm Transplantation | - |
dc.subject.keyword | Neoplastic Stem Cells/immunology | - |
dc.subject.keyword | Neoplastic Stem Cells/metabolism* | - |
dc.subject.keyword | Proto-Oncogene Proteins/genetics | - |
dc.subject.keyword | Proto-Oncogene Proteins/immunology | - |
dc.subject.keyword | Proto-Oncogene Proteins/metabolism | - |
dc.subject.keyword | Proto-Oncogene Proteins c-akt/genetics | - |
dc.subject.keyword | Proto-Oncogene Proteins c-akt/immunology | - |
dc.subject.keyword | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.keyword | Signal Transduction/genetics | - |
dc.subject.keyword | Signal Transduction/immunology* | - |
dc.subject.keyword | Transcription, Genetic/genetics | - |
dc.subject.keyword | Transcription, Genetic/immunology | - |
dc.subject.keyword | Transplantation, Heterologous | - |
dc.subject.keyword | Tumor Escape* | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Han Byoul | - |
dc.citation.volume | 122 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 4077 | - |
dc.citation.endPage | 4093 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL INVESTIGATION, Vol.122(11) : 4077-4093, 2012 | - |
dc.identifier.rimsid | 33469 | - |
dc.type.rims | ART | - |
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