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Bioactivity and mechanical properties of collagen composite membranes reinforced by chitosan and β-tricalcium phosphate

Authors
 Sang-Bae Lee ; Jae-Sung Kwon ; Kyoung-Nam Kim ; Kwang-Mahn Kim ; Yong-Keun Lee 
Citation
 Journal of Biomedical Materials Research Part B-Applied Biomaterials, Vol.100(7) : 1935~1942, 2012 
Journal Title
 Journal of Biomedical Materials Research Part B-Applied Biomaterials 
ISSN
 1552-4973 
Issue Date
2012
Abstract
In this study, we analyzed the effects of varying concentrations of chitosan (CS) and β-tricalcium phosphate [β-TCP, Ca(3)(PO(4))(2)] on the mechanical and cell-adhesion properties of a collagen (CG) matrix for use in guided bone regeneration (GBR). Three different CS concentrations (0.5, 1, and 2%) and five different contents of β-TCP (0, 17, 29, 38, and 44%) were investigated. The composite membranes were analyzed by scanning electron microscopy and cell-adhesion, flexural-strength, and tear-strength assays. The results show that the cell-adhesion and mechanical properties of the composite membranes improved with increasing β-TCP and CS contents, yielding suitable levels of the adhesion of cells and adequate mechanical stability to ensure successful GBR. The CS adhered to the microsized β-TCP, which was distributed uniformly in the composite membranes. The β-TCP and CS have no negative effect on the cell morphology, viability, and proliferation and possess good biocompatibility. This study demonstrates that β-TCP/CS/CG composite membranes are good candidates for GBR membranes in future applications.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90630
DOI
10.1002/jbm.b.32760
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Dental Engineering
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.32760/abstract
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