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Association between choroidal thickness and ocular perfusion pressure in young, healthy subjects: enhanced depth imaging optical coherence tomography study.

Title
 Association between choroidal thickness and ocular perfusion pressure in young, healthy subjects: enhanced depth imaging optical coherence tomography study. 
Authors
 Min Kim ; Sung Soo Kim ; Sung Chul Lee ; Hyoung Jun Koh ; Hee Jung Kwon 
Issue Date
2012
Journal Title
 Investigative Ophthalmology & Visual Science 
ISSN
 0146-0404 
Citation
 Investigative Ophthalmology & Visual Science, Vol.53(12) : 7710~7717, 2012 
Abstract
PURPOSE: To investigate the correlation of choroidal thickness (CT) with ocular perfusion pressure (OPP) in young, healthy subjects using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS: A single horizontal section and a single vertical section of EDI-OCT scans in each eye of 69 young, healthy subjects were obtained at the macula. CT was measured at the fovea, and up to 3 mm, at intervals of 0.5 mm, away from the fovea in the superior, inferior, nasal, and temporal choroid. Univariable and multivariable analyses were performed to assess the association of CT with OPP while axial length (AL), refractive error (RE), sex, and/or body mass index (BMI), were taken into consideration. RESULTS: Mean subfoveal CT was 307.03 ± 91.27 μm (mean age, 22.3 ± 3 years; mean axial length, 25.35 ± 1.14 mm; mean refractive error, -3.89 ± 2.02 diopters; mean OPP, 44.18 ± 5.49 mm Hg). Multivariable regression analysis showed that in eyes with <6 diopters of myopia, subfoveal CT (325.92 ± 88.46 μm) changed most significantly in association with RE and mean OPP (β = 25.941, P < 0.001; β = -3.551, P = 0.042, respectively; adjusted R(2) = 0.249). In subjects with myopia of >6 diopters, subfoveal CT (225.17 ± 49.37 μm) was significantly thinner (P < 0.0001), and a significant correlation with OPP was not observed (P > 0.05). CONCLUSIONS: In vivo subfoveal CT as measured by EDI-OCT was significantly associated with OPP in young, healthy subjects when adjusted for RE, suggesting that subfoveal CT may be indirectly indicative of subfoveal ocular perfusion status. This association was not observed in subjects with high myopia.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90572
DOI
10.1167/iovs.12-10464.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Ophthalmology
Yonsei Authors
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Link
 http://www.iovs.org/content/53/12/7710
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