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Pulmonary hypertension associated with rheumatic diseases: baseline characteristics from the Korean registry.

Title
Pulmonary hypertension associated with rheumatic diseases: baseline characteristics from the Korean registry.
Authors
Chan Hong Jeon;Ji-Young Chai;Soo-Kon Lee;Eun-Mi Koh;Jae-Bum Jun;Young-Il Seo
Issue Date
2012
Journal Title
International Journal of Rheumatic Diseases
ISSN
1756-1841
Citation
International Journal of Rheumatic Diseases, Vol.15(5) : e80~e89, 2012
Abstract
OBJECTIVES: The REgistry of Pulmonary Hypertension Associated with Rheumatic Disease (REOPARD) was established in Korea. The baseline data are described from the second year of the registry's operation. METHODS: Patients with a connective tissue disease (CTD) who met the modified definition of the WHO group I pulmonary arterial hypertension (PAH) were enrolled. PAH was defined as a systolic pulmonary arterial pressure> 40 mmHg by echocardiography or mean pulmonary arterial pressure> 25 mmHg by right heart catheterization. Hemodynamic parameters and clinical data such as demographics, functional class, underlying disease, organ involvement, laboratory tests and current treatment were recorded. RESULTS: A total of 321 patients were enrolled during the 2-year study period from 2008 to 2010. The mean age of the patients at registration was 51.9 years and 87.5% were female. Most patients were diagnosed by echocardiography and only 24 patients (7.5%) underwent cardiac catheterization. Exertional dyspnea was present in 63.6% of patients and 31.8% were New York Heart Association class III or IV. Among the patients, systemic lupus erythematosus accounted for 35.3%, systemic sclerosis 28.3%, rheumatoid arthritis 7.8%, overlap syndrome 9.0%, and mixed connective tissue disease 5.9%. There were no significant differences in hemodynamics, functional class, diffusing capacity and N-terminal pro-brain natriuretic peptide levels between the disease subgroups. Treatments consisted of calcium antagonists (57.0%), endothelin antagonists (32.7%), prostanoids (27.1%), phosphodiesterase-5 inhibitors (14.3%) and combinations (37.4%). CONCLUSION: Compared with previous studies, the results showed some differences: underlying diseases, functional status and treatments. This may be due to differences in ethnic background and diagnostic methods of our study.
URI
http://onlinelibrary.wiley.com/doi/10.1111/j.1756-185X.2012.01815.x/abstract

http://ir.ymlib.yonsei.ac.kr/handle/22282913/90546
DOI
10.1111/j.1756-185X.2012.01815.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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