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Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy.

Authors
 Dong Jin Lee ; Ga Young Park ; Eun Seong Lee ; Jin woo Park ; Young Taik Oh ; Yu Seok Youn ; Dong Sup Kwag ; Nam Muk Oh ; Kyung Taek Oh 
Citation
 International Journal of Pharmaceutics, Vol.434(1-2) : 257~263, 2012 
Journal Title
 International Journal of Pharmaceutics 
ISSN
 0378-5173 
Issue Date
2012
Abstract
Poly (lactide-co-glycolide) (PLGA) coupled with methoxy poly (ethylene glycol) (mPEG) or chlorin e6 (Ce6) was synthesized using the Steglich esterification method. PLGA-linked mPEG (PLGA-mPEG), PLGA-linked Ce6 (PLGA-Ce6), and Fe(3)O(4) were utilized to constitute multifunctional PLGA nanoparticles (∼160 nm) via the multi-emulsion W(1)/O/W(2) (water-in-oil-in-water) method. The photo-sensitizing properties of Ce6 molecules anchored to PLGA nanoparticles enabled in vivo luminescence imaging and photodynamic therapy for the tumor site. The encapsulation of Fe(3)O(4) allowed high contrast magnetic resonance (MR) imaging of the tumor in vivo. Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex(®) (commercial contrast agent).
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90518
DOI
10.1016/j.ijpharm.2012.05.068
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0378517312005881
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