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The Transcription Factor Mist1 Regulates the Cellular Polarity in Mouse Pancreatic Acinar Cells Pancreatic Acinar Cells

Title
The Transcription Factor Mist1 Regulates the Cellular Polarity in Mouse Pancreatic Acinar Cells Pancreatic Acinar Cells
Authors
Yu-Mi Yang;Syng-Ill Lee;Dong Min Shin
Issue Date
2012
Journal Title
International Journal of Oral Biology
ISSN
1226-7155
Citation
International Journal of Oral Biology, Vol.37(1) : 37~41, 2012
Abstract
Pancreatic acinar cells exhibit a polarity that is characterized by the localization of secretory granules at the apical membrane. However, the factors that regulate cellular polarity in these cells are not well understood. In this study, we investigated the effect of Mist1, a basic helix-loop-helix transcription factor, on the cellular architecture of pancreatic acinar cells. Mist1-null mice displayed secretory granules that were diffuse throughout the pancreatic acinar cells, from the apical to basolateral membranes, whereas Mist1 heterozygote mice showed apical localization of secretory granules. Deletion of the Mist1 gene decreased the expression of type 3 inositol 1,4,5-triphosphate receptors (IP3R) but did not affect apical localization and expression of IP3R2. Mist1- null mice also displayed an increase in luminal areas and an increase in the expression of zymogen granules in pancreatic acinar cells. These results suggest that Mist1 plays a critical role in polar localization of cellular organelles and in maintaining cellular architecture in mouse pancreatic acinar cells.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/90510
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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