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EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity.

Authors
 Yoo-Hyun Lee ; Jieun Kwak ; Ho-Geun Yoon ; Hyun-Jin Park ; Woojin Jun ; Jeongmin Lee ; Sunoh Kim ; Kyung-Chul Choi ; Hyo-Kyoung Choi 
Citation
 International Journal of Molecular Medicine, Vol.30(1) : 69~74, 2012 
Journal Title
 International Journal of Molecular Medicine 
ISSN
 1107-3756 
Issue Date
2012
Abstract
Manipulating acetylation status of key gene targets is likely to be crucial for effective cancer therapy. In this study, we utilized green tea catechins, epicatechin (EC), epigallocatechin (EGC) and epigallocatechin-3-gallate (EGCG) to examine the regulation of androgen receptor acetylation in androgen-dependent prostate cancer cells by histone acetyl-transferase (HAT) activity. EC, EGC and EGCG induced prostate cancer cell death, suppressed agonist-dependent androgen receptor (AR) activation and AR-regulated gene transcription. These results demonstrated a similar tendency to HAT inhibitory activities; EGCG>EGC>EC. The strongest HAT inhibitor among them, EGCG (50 µM), downregulated AR acetylation and finally, AR protein translocation to nucleus from the cytoplasmic compartment was effectively inhibited in the presence of the agonist. These results suggest another mechanism to develop effective therapeutics based on green tea catechins.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90495
DOI
10.3892/ijmm.2012.966
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biochemistry & Molecular Biology
Yonsei Authors
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Link
 http://www.spandidos-publications.com/ijmm/30/1/69
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