Cited 7 times in

Allele frequencies of human leukocyte antigen-G in a Korean population.

Title
Allele frequencies of human leukocyte antigen-G in a Korean population.
Authors
Y. Park;Y. S. Kim;H.-S. Kim;O. J. Kwon
Issue Date
2012
Journal Title
International Journal of Immunogenetics
ISSN
1744-3121
Citation
International Journal of Immunogenetics, Vol.39(1) : 39~45, 2012
Abstract
The human leukocyte antigen (HLA)-G is a nonclassical major histocompatibility complex class I molecule with relatively limited polymorphism. The differences in allele frequency according to ethnicity and country have not been studied enough, so far. Therefore, fundamental data including allele frequencies and polymorphism are needed for studies on immunological function of HLA-G in each population. We investigated allele frequencies and 14-bp polymorphism of the HLA-G in Koreans. HLA-G alleles and 14-bp polymorphisms were determined by sequence-based typing analysis of exons 2-4 and polymerase chain reaction of exon 8 in 200 unrelated individuals. Genotyping analysis identified eight different HLA-G alleles, which indicates that the Korean population presents limited HLA-G allelic polymorphism. HLA-G*01:01:01:01 and G*01:04:01 were frequent alleles (42.5% and 34.0%), and allelic frequencies were similar to those of other Asian populations. The 14-bp deletion alleles are higher (78%) in Koreans, although the frequencies of the 14-bp insertion/deletion polymorphism have been known to be nearly equal in many Caucasian populations. HLA-G*01:01:08 was reported strong linkage disequilibrium with the 14-bp deletion in a previous report; the same allele was accompanied with 14-bp insertion in our study. There are a few studies investigating allele frequencies, and most of them were studied before high-resolution method era. This is the first study regarding HLA-G genotypes in Korean, which were identified by high-resolution method. From this study, we identified HLA-G frequencies of a Korean population and expect this study could help further investigations for immunological and clinical implications of HLA-G.
URI
http://onlinelibrary.wiley.com/doi/10.1111/j.1744-313X.2011.01053.x/abstract

http://ir.ymlib.yonsei.ac.kr/handle/22282913/90477
DOI
10.1111/j.1744-313X.2011.01053.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse