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Differences in coronary plaque composition with aging measured by coronary computed tomography angiography.

Title
 Differences in coronary plaque composition with aging measured by coronary computed tomography angiography. 
Authors
 Rajesh Tota-Maharaj ; Michael J. Blaha ; Khurram Nasir ; Hyuk-Jae Chang ; Roger S. Blumenthal ; Sang-il Choi ; Eun Ju Chun ; Yeonyee E. Yoon ; Sung-A Chang ; Eue-Keun Choi ; Travis S. Henry ; Juan J. Rivera 
Issue Date
2012
Journal Title
 International Journal of Cardiology 
ISSN
 0167-5273 
Citation
 International Journal of Cardiology, Vol.158(2) : 240~245, 2012 
Abstract
BACKGROUND: Little is known about the independent impact of aging on coronary plaque morphology and composition in the era of cardiac computed tomography angiography (CCTA). METHODS: We studied 1015 consecutive asymptomatic South Korean subjects (49 ± 10 years, 64% men) who underwent 64-slice CCTA during routine health evaluation. Coronary plaque characteristics were analyzed on a per-segment basis according to the modified AHA classification. Plaques with >50% calcified tissue were classified as calcified (CAP), plaques with <50% calcified tissue were classified as mixed (MCAP), and plaques without calcium were classified as non-calcified (NCAP). Multiple regression analysis was employed to describe the cross-sectional association between age tertile and plaque type burden (≥ 2 affected segments) after adjustment for other cardiovascular risk factors. RESULTS: The prevalence of coronary plaque increased with age, (1st tertile: 7.5%, 3rd tertile: 38.5% [p<0.001]). The relative contribution of NCAP to overall plaque burden decreased with age from nearly 50% in the first tertile to approximately 20% in the third, while there was a reciprocal increase in both MCAP and CAP subtypes. In multivariable analysis, patients in the oldest tertile had a 2.5-fold increase in burden of NCAP, yet a nearly 40-fold increase in MCAP and 16-fold increase in CAP compared to the youngest tertile. In conclusion, CCTA is an effective method for measuring age-related differences in the burden of individual coronary plaque subtypes. Future research is needed to determine whether the increase in mixed and calcified plaques seen with aging produce an independent contribution to the age-related increase in cardiovascular risk.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90446
DOI
10.1016/j.ijcard.2011.01.041
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0167527311000714
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