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BMP4 signaling mediates Zeb family in developing mouse tooth.

Authors
 권혁제 ; 김은정 ; 나까가와에이죠 ; 신정오 ; 정한성 ; 조경원 ; 조성원 
Citation
 Histochemistry and Cell Biology, Vol.137(6) : 791~800, 2012 
Journal Title
 Histochemistry and Cell Biology 
ISSN
 0948-6143 
Issue Date
2012
Abstract
Tooth morphogenesis is regulated by sequential and reciprocal interaction between oral epithelium and neural-crest-derived ectomesenchyme. The interaction is controlled by various signal molecules such as bone morphogenetic protein (BMP), Hedgehog, fibroblast growth factor (FGF), and Wnt. Zeb family is known as a transcription factor, which is essential for neural development and neural-crest-derived tissues, whereas the role of the Zeb family in tooth development remains unclear. Therefore, this study aimed to investigate the expression profiles of Zeb1 and Zeb2 during craniofacial development focusing on mesenchyme of palate, hair follicle, and tooth germ from E12.5 to E16.5. In addition, we examined the interaction between Zeb family and BMP4 during tooth development. Both Zeb1 and Zeb2 were expressed at mesenchyme of the palate, hair follicle, and tooth germ throughout the stages. In the case of tooth germ at the cap stage, the expression of Zeb1 and Zeb2 was lost in epithelium-separated dental mesenchyme. However, the expression of Zeb1 and Zeb2 in the dental mesenchyme was recovered by Bmp4 signaling via BMP4-soaked bead and tissue recombination. Our results suggest that Zeb1 and Zeb2, which were mediated by BMP4, play an important role in neural-crest-derived craniofacial organ morphogenesis, such as tooth development.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90372
DOI
10.1007/s00418-012-0930-7
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs00418-012-0930-7
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