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Effect of Ligand Structure on MnO Nanoparticles for Enhanced T1 Magnetic Resonance Imaging of Inflammatory Macrophages

Authors
 서진석 ; 양재문 ; 임은경 ; 허용민 
Citation
 European Journal of Inorganic Chemistry, Vol.2012 : 5960~5965, 2012 
Journal Title
 European Journal of Inorganic Chemistry 
ISSN
 1434-1948 
Issue Date
2012
Abstract
Carboxymethyl-dextran (CM-dextran) replaced the hydrophobic oleylamine ligands on the surfaces of MnO nanoparticles, rendering them highly water-soluble by allowing direct contact with excited water protons. Solution MRI studies of the two types of nanoparticles, exchanged and bilayered, with different core sizes have shown that the exchanged ligand structure exhibits significantly enhanced longitudinal relaxation. The modification with dextran converted the nanoparticles into effective T1 MRI contrast agents, as well as promoting strong interactions with macrophages. Thus, it is a potential MR contrast agent for visualizing inflammatory macrophages.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90201
DOI
10.1002/ejic.201201026
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
1. 연구논문 > 5. Research Institutes > Institute for Medical Convergence
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/ejic.201201026/abstract
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