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A randomized phase II trial of S-1-oxaliplatin versus capecitabine-oxaliplatin in advanced gastric cancer.

Title
A randomized phase II trial of S-1-oxaliplatin versus capecitabine-oxaliplatin in advanced gastric cancer.
Authors
Gun Min Kim;Hei-Cheul Jeung;Hyun Cheol Chung;Kyung Hee Lee;Byung Ho Nam;Inkyung Jung;Hyo Song Kim;Sun Young Rha
Issue Date
2012
Journal Title
European Journal of Cancer
ISSN
0959-8049
Citation
European Journal of Cancer, Vol.48(4) : 518~526, 2012
Abstract
PURPOSE: S-1 or capecitabine plus oxaliplatin are considered active and tolerable in gastric cancer patients. We conducted a randomized phase II trial in gastric cancer patients to compare the activity and safety of these combinations. METHODS: The patients received S-1 at 80 mg/m2 for 14 days, followed by a 7-day rest period within a 3-week schedule in the S-1/oxaliplatin (SOX) arm, and capecitabine at 2000 mg/m2 for 14 days, followed by a 7-day rest period within a 3-week schedule in the capecitabine/oxaliplatin (CAPOX) arm. Oxaliplatin 130 mg/m2 was administered every 3 weeks in both arms. RESULTS: One hundred twenty-nine patients were randomly assigned to SOX (N=65) or CAPOX (N=64). The median time to progression and the overall survival were 6.2 and 12.4 months with SOX, respectively; and 7.2 and 13.3 months with CAPOX, respectively. The overall response rates were 40% and 44% for SOX and CAPOX, respectively. The most frequent grade 3 or 4 toxicities were thrombocytopenia (15.4%) for SOX and neutropenia (18.8%) for CAPOX. The median time to 10% deteriorations in global health scores was similar in both arms (SOX, 4.3 months, CAPOX, 4.9 months). CONCLUSION: Both the SOX and CAPOX regimens were equally active and well tolerated in advanced gastric cancer patients.
URI
http://www.sciencedirect.com/science/article/pii/S0959804911010665

http://ir.ymlib.yonsei.ac.kr/handle/22282913/90191
DOI
10.1016/j.ejca.2011.12.017
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biostatistics
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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