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Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients.
DC Field | Value | Language |
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dc.contributor.author | 오형중 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 유동은 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 김승준 | - |
dc.contributor.author | 최규헌 | - |
dc.contributor.author | 한대석 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2014-12-19T16:46:15Z | - |
dc.date.available | 2014-12-19T16:46:15Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0918-8959 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90161 | - |
dc.description.abstract | In patients with end-stage renal disease (ESRD), circulating adipokine levels are increased due to decreased renal clearance, irrespective of obesity. However, whether adipokines play a role in the development of insulin resistance (IR) in non-obese ESRD patients is unknown. We conducted a cross-sectional study to identify factors associated with IR in 62 non-obese patients on peritoneal dialysis (PD). Non-obesity was defined as body mass index (BMI) <25 kg/m(2). IR was determined using homeostatic model assessment-IR (HOMA-IR). We also measured serum concentrations of adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hsCRP), and IL-6. The average BMI of the study patients was 21.6 kg/m(2). When patients were divided into two groups according to the median value of HOMA-IR, serum adiponectin levels were significantly lower in patients with HOMA-IR > 1.85 than in those with HOMA-IR ≤1.85, whereas serum concentrations of leptin and resistin did not differ between the two groups. In addition, log-transformed HOMA-IR was negatively correlated with adiponectin (γ = -0.464, P < 0.001) and log-transformed high-density lipoprotein cholesterol (γ = -0.250, P = 0.050) and positively correlated with age (γ = 0.334, P = 0.008) and triglyceride (γ = 0.392, P = 0.002). However, resistin, log-transformed leptin and log-transformed hsCRP were not associated with HOMA-IR. In a multiple linear regression model, adiponectin was independently associated with HOMA-IR (β = -0.023, P = 0.015). In conclusion, this study suggests that low circulating adiponectin levels might be involved in IR even in non-obese patients undergoing PD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | ENDOCRINE JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin/blood* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | C-Reactive Protein/metabolism | - |
dc.subject.MESH | Cholesterol, HDL/blood | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Homeostasis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance* | - |
dc.subject.MESH | Interleukin-6/blood | - |
dc.subject.MESH | Kidney Failure, Chronic/blood | - |
dc.subject.MESH | Leptin/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Models, Biological | - |
dc.subject.MESH | Peritoneal Dialysis | - |
dc.subject.MESH | Resistin/blood | - |
dc.title | Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Dong Eun Yoo | - |
dc.contributor.googleauthor | Mi Jung Lee | - |
dc.contributor.googleauthor | Hyung Jung Oh | - |
dc.contributor.googleauthor | Seung Jun Kim | - |
dc.contributor.googleauthor | Dong Ho Shin | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.contributor.googleauthor | Dae Suk Han | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 22673293 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02417 | - |
dc.contributor.localId | A02461 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A02097 | - |
dc.contributor.localId | A04043 | - |
dc.contributor.localId | A04272 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A00659 | - |
dc.contributor.localId | A02773 | - |
dc.relation.journalcode | J00769 | - |
dc.identifier.eissn | 1348-4540 | - |
dc.identifier.pmid | 22673293 | - |
dc.subject.keyword | Insulin resistance | - |
dc.subject.keyword | Non-obese | - |
dc.subject.keyword | Peritoneal dialysis | - |
dc.subject.keyword | Adipokine | - |
dc.subject.keyword | Chronic inflammation | - |
dc.contributor.alternativeName | Oh, Hyung Jung | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Yoo, Dong Eun | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Kim, Seung Jun | - |
dc.contributor.alternativeName | Shin, Dong Ho | - |
dc.contributor.alternativeName | Choi, Kyu Hun | - |
dc.contributor.alternativeName | Han, Dae Suk | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Dong Eun | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | Choi, Kyu Hun | - |
dc.contributor.affiliatedAuthor | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Kim, Seung Jun | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.citation.volume | 59 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 685 | - |
dc.citation.endPage | 695 | - |
dc.identifier.bibliographicCitation | ENDOCRINE JOURNAL, Vol.59(8) : 685-695, 2012 | - |
dc.identifier.rimsid | 32398 | - |
dc.type.rims | ART | - |
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