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Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.

Title
 Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. 
Authors
 Yun-Yong Park ; Kyounghyun Kim ; Sang-Bae Kim ; Bryan T. Hennessy ; Soo Mi Kim ; Eun Sung Park ; Jae Yun Lim ; Jane Li ; Yiling Lu ; Ana Maria Gonzalez-Angulo ; Woojin Jeong ; Gordon B. Mills ; Stephen Safe ; Ju-Seog Lee 
Issue Date
2012
Journal Title
 EMBO Molecular Medicine 
ISSN
 1757-4676 
Citation
 EMBO Molecular Medicine, Vol.4(1) : 52~67, 2012 
Abstract
ESR1 is one of the most important transcription factors and therapeutic targets in breast cancer. By applying systems-level re-analysis of publicly available gene expression data, we uncovered a potential regulator of ESR1. We demonstrated that orphan nuclear receptor NR2E3 regulates ESR1 via direct binding to the ESR1 promoter with concomitant recruitment of PIAS3 to the promoter in breast cancer cells, and is essential for physiological cellular activity of ESR1 in estrogen receptor (ER)-positive breast cancer cells. Moreover, expression of NR2E3 was significantly associated with recurrence-free survival and a favourable response to tamoxifen treatment in women with ER-positive breast cancer. Our results provide mechanistic insights on the regulation of ESR1 by NR2E3 and the clinical relevance of NR2E3 in breast cancer
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90158
DOI
10.1002/emmm.201100187
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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