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Mitochondria DNA polymorphisms are associated with susceptibility to endometriosis.

Authors
 SiHyun Cho ; Young-Mock Lee ; Byung Seok Lee ; Seok Kyo Seo ; Hye Yeon Kim ; KyungJin Lim ; Kyung Eun Lee ; Young Eun Jeon ; Hyo In Yang ; Young Sik Choi 
Citation
 DNA and Cell Biology, Vol.31(3) : 317~322, 2012 
Journal Title
 DNA and Cell Biology 
ISSN
 1044-5498 
Issue Date
2012
Abstract
Because energy production involves oxidative phosphorylation, mitochondria are major sources of reactive oxygen species in the cell. Recent findings indicate that mitochondrial DNA (mtDNA) variants may play a role in the etiology of certain autoimmune and chronic inflammatory diseases. The aim of this study was to investigate the possible association between mtDNA polymorphisms and susceptibility to endometriosis. This study included 198 patients with histologically confirmed endometriosis and 167 patients without endometriosis as controls. Common variants of mtDNA at nt10398 (A/G transition), nt13708 (G/A transition), and nt16189 (T/C transition) were detected using polymerase chain reaction. An association study was performed with a chi-square test and logistic regression analysis. The prevalence of the mtDNA nt16189 variant was higher in patients with endometriosis (46.0%, 91 of 198) than in controls (34.7%, 58 of 167) (p=0.030) with odds ratio (OR) of 1.98 (95% confidence interval [CI]: 1.04-3.78). A combination of the 10398 and 16189 variants was also associated with increased risk for endometriosis (OR=1.90, 95% CI: 1.13-3.18, p=0.015). These associations remained significant even after adjusting for age and body mass index. Our data strongly suggest that the mtDNA 16189 variants and the combination of mtDNA 16189 and 10398 variants increase susceptibility to endometriosis
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90155
DOI
10.1089/dna.2011.1279
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
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Link
 http://online.liebertpub.com/doi/abs/10.1089/dna.2011.1279
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