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Efficacy of leukotriene receptor antagonist for erosive esophagitis: a preliminary retrospective comparative study.
DC Field | Value | Language |
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dc.contributor.author | 이혁 | - |
dc.contributor.author | 박준철 | - |
dc.contributor.author | 신성관 | - |
dc.contributor.author | 이상길 | - |
dc.contributor.author | 이용찬 | - |
dc.date.accessioned | 2014-12-19T16:46:01Z | - |
dc.date.available | 2014-12-19T16:46:01Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1120-8694 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90154 | - |
dc.description.abstract | While diagnostic overlap exists between gastroesophageal reflux disease and eosinophilic esophagitis especially on histological findings, therapeutic approaches for the two disease entities are very different. Recently, anti-inflammatory treatment, in addition to acid suppressants, has been investigated for gastroesophageal reflux disease. This study investigated whether the incidence of endoscopic erosive esophagitis was lower in recipients of long-term leukotriene receptor antagonist (LTRA) treatment. This retrospective comparative study included 207 recipients of an LTRA and an equal number of controls who underwent screening upper endoscopic examination. Twenty-two (10.6%) and 51 (24.6%) cases of erosive esophagitis were detected in the LTRA and control groups, respectively (P < 0.001). A significantly higher incidence of minimal change esophagitis was also found in the controls compared with the LTRA group (14.5% vs. 2.4%, P < 0.001). On multivariate analysis, LTRA treatment was significantly and inversely associated with erosive esophagitis (odds ratio [OR], 0.25; 95% confidence interval [CI], 0.13 to 0.46). Within the LTRA treatment group, an increased risk of erosive esophagitis was strongly associated with the presence of hiatal hernia (OR, 5.89; 95% CI, 2.20-15.73, P < 0.001) and short duration of LTRA treatment (OR, 0.64; 95% CI, 0.37-0.89, P= 0.022). In conclusion, this preliminary retrospective analysis demonstrated that patients who underwent long-term treatment with a LTRA had low incidence of endoscopic minimal change esophagitis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 595~599 | - |
dc.relation.isPartOf | DISEASES OF THE ESOPHAGUS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetates/therapeutic use* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asthma/complications | - |
dc.subject.MESH | Asthma/drug therapy | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Esophagitis, Peptic/complications | - |
dc.subject.MESH | Esophagitis, Peptic/drug therapy* | - |
dc.subject.MESH | Esophagoscopy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastroesophageal Reflux/complications | - |
dc.subject.MESH | Gastroesophageal Reflux/drug therapy* | - |
dc.subject.MESH | Hernia, Hiatal/complications | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukotriene Antagonists/therapeutic use* | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Quinolines/therapeutic use* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Efficacy of leukotriene receptor antagonist for erosive esophagitis: a preliminary retrospective comparative study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | H. Lee | - |
dc.contributor.googleauthor | J. C. Park | - |
dc.contributor.googleauthor | S. K. Shin | - |
dc.contributor.googleauthor | S. K. Lee | - |
dc.contributor.googleauthor | Y. C. Lee | - |
dc.identifier.doi | 22211520 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03285 | - |
dc.contributor.localId | A01676 | - |
dc.contributor.localId | A02112 | - |
dc.contributor.localId | A02812 | - |
dc.contributor.localId | A02988 | - |
dc.relation.journalcode | J00745 | - |
dc.identifier.eissn | 1442-2050 | - |
dc.identifier.pmid | 22211520 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1442-2050.2011.01299.x/abstract | - |
dc.subject.keyword | endoscopy | - |
dc.subject.keyword | esophagitis | - |
dc.subject.keyword | gastroesophageal reflux | - |
dc.subject.keyword | leukotriene antagonists | - |
dc.contributor.alternativeName | Lee, Hyuk | - |
dc.contributor.alternativeName | Park, Jun Chul | - |
dc.contributor.alternativeName | Shin, Sung Kwan | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Lee, Hyuk | - |
dc.contributor.affiliatedAuthor | Park, Jun Chul | - |
dc.contributor.affiliatedAuthor | Shin, Sung Kwan | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.citation.volume | 25 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 595 | - |
dc.citation.endPage | 599 | - |
dc.identifier.bibliographicCitation | DISEASES OF THE ESOPHAGUS, Vol.25(7) : 595-599, 2012 | - |
dc.identifier.rimsid | 32394 | - |
dc.type.rims | ART | - |
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