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Liver stiffness measurement using acoustic radiation force impulse (ARFI) elastography and effect of necroinflammation.

Title
 Liver stiffness measurement using acoustic radiation force impulse (ARFI) elastography and effect of necroinflammation.
Authors
 Ki Tae Yoon; Sun Min Lim; Seung Up Kim; Jun Woo Lee; Mong Cho; Chae Yoon Chon; Kwang-Hyub Han; Sang Hoon Ahn; Do Young Kim; Jun Yong Park
Issue Date
2012
Journal Title
 Digestive Diseases and Sciences
ISSN
 0163-2116
Citation
 Digestive Diseases and Sciences, Vol.57(6) : 1682~1691, 2012
Abstract
BACKGROUND: Acoustic radiation force impulse (ARFI) elastography can be used to assess the degree of liver fibrosis. AIM: We evaluated the performance of ARFI elastography in assessment of liver fibrosis and compared it with the performance of aspartate aminotransferase-to-platelet ratio index (APRI) and transient elastography with Fibroscan (FS). METHODS: We prospectively analyzed 250 consecutive patients who underwent liver biopsy and ARFI from June 2010 to May 2011. Reliable FS values were obtained for 97 (38.8%) patients. RESULTS: The mean age of patients (147 male and 103 female) was 46.6 years. Liver stiffness values obtained by use of ARFI elastography significantly correlated with histological fibrosis stage (R = 0.575, P < 0.001). Area under the receiver operating characteristics curves (AUROCs) of ARFI elastography for predicting significant fibrosis (≥F2) and cirrhosis (F4) was 0.74 (95% confidence interval [CI], 0.64-0.86, P = 0.001) and 0.79 (95% CI, 0.67-0.91, P = 0.001), respectively, and those for APRI were 0.69 (95% CI, 0.58-0.79, P = 0.001) and 0.76 (95% CI, 0.64-0.85, P < 0.001), respectively. The optimum cutoff values for ARFI elastography were 1.13 m/s for ≥F2 and 1.98 m/s for F4; these decreased to 1.09 m/s for ≥F2 and 1.81 m/s for F4 when 131 patients with normal alanine aminotransferase (ALT) were selected. In the sub-group of 97 patients with reliable FS values, the performance in predicting ≥F2 or F4 was equivalent between ARFI elastography and FS. CONCLUSIONS: ARFI elastography is a reliable surrogate marker of liver fibrosis, if its relationship with biochemical markers, for example ALT level, is taken into account.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90144
DOI
10.1007/s10620-012-2044-4
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs10620-012-2044-4
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